An enantio-controlled route to (+)-vincamine (1), an eburnane alkaloid used as cerebral vasodilator, has been developed starting from the optically active enedione (2) which can be easily obtained by asymmetric aldol cyclization.
S. Takano, S. Sato, E. Goto and K. Ogasawara, J. Chem. Soc., Chem. Commun., 1986, 156 DOI: 10.1039/C39860000156
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