Acylation of the dianion (1) derived from ethyl hippurate (2) using anhydrides, followed by acid hydrolysis, provides a general route to α-aminoketones; a short and convenient preparation of the porphyrin precursor δ-aminolevulinic acid (as the hydrochloride) by the foregoing procedure is described.
D. A. Evans and P. J. Sidebottom, J. Chem. Soc., Chem. Commun., 1978, 753 DOI: 10.1039/C39780000753
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