The homoconjugate addition of Grignard reagents to spiroactivated cyclopropanes has been used for the conversion of the readily available cyclopropane (6a) into the key intermediate (4) for the preparation of (±)-brefeldin A.
T. Livinghouse and R. V. Stevens, J. Chem. Soc., Chem. Commun., 1978, 754 DOI: 10.1039/C39780000754
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