The stobbe condensation of 3,4-disubstituted acetophenones with diethyl succinate
Abstract
3,4-Dimethyl-, 3,4-dimethoxy-, and 3,4-dichloroacetophenone were condensed with diethyl succinate in the presence of potassium t-butoxide, and the resulting half-esters were cyclised to naphthalene derivatives (II) or oxoindenyl acids (V) according to their configuration.