Themed collection Journal of Materials Chemistry B Emerging Investigators 2024
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In vivo photopharmacological inhibition of hippocampal activity via multimodal probes – perspective and opening steps on experimental and computational challenges
A new perspective for the study/treatment of neurological conditions using in vivo photopharmacology is presented, including initial experimental and computational data.
J. Mater. Chem. B, 2024, Advance Article
https://doi.org/10.1039/D4TB01117A
A novel method for the diagnosis of atherosclerosis based on nanotechnology
The integration of nanotechnology and medicine is a significant trend in modern healthcare, with a particular focus on its utilization in atherosclerosis imaging, presenting immense potential for advancement.
J. Mater. Chem. B, 2024, Advance Article
https://doi.org/10.1039/D4TB00900B
Hydrogels: a promising therapeutic platform for inflammatory skin diseases treatment
Hydrogels revolutionize treating chronic skin diseases by enhancing drug delivery and reducing side effects. This review explores hydrogel design, drug integration, and clinical trials, highlighting their potential to improve efficacy and safety.
J. Mater. Chem. B, 2024,12, 8007-8032
https://doi.org/10.1039/D4TB00887A
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Methods to achieve tissue-mimetic physicochemical properties in hydrogels for regenerative medicine and tissue engineering
Hydrogels are limited by their inability to recapitulate native extracellular physicochemical properties. Current efforts using advanced materials science and engineering methods seek to form hydrogels with physiologically-relevant properties.
J. Mater. Chem. B, 2024, Advance Article
https://doi.org/10.1039/D4TB00716F
Nanomaterial Combined Engineered Bacteria for Intelligent Tumor Immunotherapy
J. Mater. Chem. B, 2024, Accepted Manuscript
https://doi.org/10.1039/D4TB00741G
Immunologically effective biomaterials enhance immunotherapy of prostate cancer
J. Mater. Chem. B, 2024, Accepted Manuscript
https://doi.org/10.1039/D3TB03044J
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Wearable and implantable biosensors: mechanisms and applications in closed-loop therapeutic systems
Biosensors integrated into closed-loop systems provide patient-specific adaptive therapies. These advanced devices have significant potential for managing chronic conditions by continuously adjusting therapeutic regimens based on physiological data.
J. Mater. Chem. B, 2024, Advance Article
https://doi.org/10.1039/D4TB00782D
Building in vitro models for mechanistic understanding of liver regeneration in chronic liver diseases
The figure shows how impaired regeneration fuels CLD progression. It depicts how 3D bioprinted models can overcome the limitations of animal models and clinical/histopathological data, and provide mechanistic insights into liver regeneration.
J. Mater. Chem. B, 2024,12, 7669-7691
https://doi.org/10.1039/D4TB00738G
Magneto-responsive biocomposites in wound healing: from characteristics to functions
Schematic illustrations of the pathways through which magneto-responsive biocomposites promote wound healing.
J. Mater. Chem. B, 2024,12, 7463-7479
https://doi.org/10.1039/D4TB00743C
A nanoparticle-assisted signal-enhancement technique for lateral flow immunoassays
This review probes the nanoparticle-assisted amplification strategies for lateral flow immunoassay.
J. Mater. Chem. B, 2024,12, 6735-6756
https://doi.org/10.1039/D4TB00865K
Recent advances in stimuli-responsive controlled release systems for neuromodulation
Stimuli-responsive controlled release systems are emerging as powerful tools for precise neuromodulation. This review summarizes the recent progress in different release mechanisms and provides insights into future research direction.
J. Mater. Chem. B, 2024,12, 5769-5786
https://doi.org/10.1039/D4TB00720D
Biological applications of lipoic acid-based polymers: an old material with new promise
This review highlights the ring-opening polymerization strategies of LA molecules and recent biomedical applications of PLA while discussing the challenges they face and future perspectives.
J. Mater. Chem. B, 2024,12, 4574-4583
https://doi.org/10.1039/D4TB00581C
Vaccine adjuvants: current status, research and development, licensing, and future opportunities
A comprehensive review of the current landscape and advancements in vaccine adjuvants, providing critical insights into research, development, regulatory licensing, and potential future opportunities for enhancing vaccine efficacy and safety.
J. Mater. Chem. B, 2024,12, 4118-4137
https://doi.org/10.1039/D3TB02861E
Enhancing spleen-targeted mRNA delivery with branched biodegradable tails in lipid nanoparticles
Ionizable lipids with branched tails enhance the selective mRNA delivery to spleen, particularly to antigen-presenting cells.
J. Mater. Chem. B, 2024,12, 8062-8066
https://doi.org/10.1039/D4TB00960F
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Heparin binding induced supramolecular chirality into the self-assembly of perylenediimide bolaamphiphile
Heparin, an anionic chiral biomolecule, binds to cationic achiral perylenediimide derivative to induce supramolecular helicity, forming chiral nanostructures in both aqueous and cell culture medium.
J. Mater. Chem. B, 2024,12, 7292-7297
https://doi.org/10.1039/D4TB00862F
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Tuneable redox-responsive albumin-hitchhiking drug delivery to tumours for cancer treatment
A novel drug delivery system hitchhiking albumin as a drug carrier with tuneable redox-responsive drug release.
J. Mater. Chem. B, 2024,12, 6563-6569
https://doi.org/10.1039/D4TB00751D
Sensing cholesterol-induced rigidity in model membranes with time-resolved fluorescence spectroscopy and microscopy
Shifting from liquid disorder to liquid order phase in liposomes restricts the microenvironment of DI-8-ANEPPS, resulting in lengthening its fluorescence lifetime.
J. Mater. Chem. B, 2024,12, 6570-6576
https://doi.org/10.1039/D4TB00872C
Highly disordered and resorbable lithiated nanoparticles with osteogenic and angiogenic properties
This study develops lithium-doped amorphous calcium phosphate nanoparticles. These bioresorbable particles promote osteogenesis and angiogenesis, effectively inducing the formation of mature ectopic bone.
J. Mater. Chem. B, 2024, Advance Article
https://doi.org/10.1039/D4TB00978A
Bacteria-responsive functional electrospun membrane: simultaneous on-site visual monitoring and inhibition of bacterial infection
Visual bacterial monitoring and responsive antimicrobial ability triggered by acid.
J. Mater. Chem. B, 2024,12, 8357-8365
https://doi.org/10.1039/D4TB00963K
Selenium nanoparticle-functionalized injectable chitosan/collagen hydrogels as a novel therapeutic strategy to enhance stem cell osteoblastic differentiation for bone regeneration
Selenium nanoparticle-functionalized injectable chitosan/collagen hydrogels for bone regeneration.
J. Mater. Chem. B, 2024, Advance Article
https://doi.org/10.1039/D4TB00984C
Broad-spectrum degradation of fluoroquinolone antibiotics by Hemin-His-Fe nanozymes with peroxidase-like activity
A novel biomimetic peroxidase nanozymes named Hemin-His-Fe (HHF)-peroxidase nanozyme was synthesized for the broad-spectrum degradation of fluoroquinolone antibiotics.
J. Mater. Chem. B, 2024, Advance Article
https://doi.org/10.1039/D4TB00508B
On-demand activatable peroxidase-mimicking enzymatic polymer nanocomposite films
The present work reports the fabrication of nanocomposite films that demonstrated precise control and tuneable on-demand enzyme-mimicking activity, thus setting up a platform for future development of smart sensors for various applications.
J. Mater. Chem. B, 2024,12, 7858-7869
https://doi.org/10.1039/D4TB00755G
Sprayable oxidized polyvinyl alcohol with improved degradability and sufficient mechanical property for fruit preservation
Oxidized PVA (OPVA-1.0) obtained by one-pot method is completely degraded in soil, which is further sprayed, dipped, or brushed conformally onto different perishable fruits to delay the ripening by 5–14 days as ideal packaging materials.
J. Mater. Chem. B, 2024, Advance Article
https://doi.org/10.1039/D4TB00896K
A 4D printed nanoengineered super bioactive hydrogel scaffold with programmable deformation for potential bifurcated vascular channel construction
Four-dimensional (4D) printing of hydrogels enabled the fabrication of complex scaffold geometries out of static parts.
J. Mater. Chem. B, 2024,12, 7604-7617
https://doi.org/10.1039/D4TB00498A
Dapansutrile OLT1177 suppresses foreign body response inflammation while preserving vascularisation of implanted materials
Selective immune suppression of the NLRP3 inflammasome by Dapansutrile (OLT1177) decreases fibrotic capsule formation and increases angiogenesis in a mouse subcutaneous implantation model of the foreign body response.
J. Mater. Chem. B, 2024,12, 7334-7347
https://doi.org/10.1039/D4TB00705K
Highly sensitive detection of Salmonella typhimurium via gold and magnetic nanoparticle-mediated sandwich hybridization coupled with ICP-MS
Foodborne pathogens including Salmonella typhimurium cause millions of illnesses annually. A novel detection method using ICP-MS with magnetic and gold nanoparticles for Salmonella typhimurium shows high specificity and sensitivity.
J. Mater. Chem. B, 2024,12, 7311-7323
https://doi.org/10.1039/D4TB00291A
A separation-free paper-based hydrogel device for one-step reactive oxygen species determination by a smartphone
A hydrogel-coupled and paper-based analytical device for H2O2 colorimetric detection by a smartphone was reported with a separation-free nature in complex biological samples.
J. Mater. Chem. B, 2024,12, 7324-7333
https://doi.org/10.1039/D4TB00715H
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Conformal encapsulation of mammalian stem cells using modified hyaluronic acid
Conformal coatings designed using a hyaluronic acid hydrogel system are used to encapsulate cells and to assemble multicellular structures.
J. Mater. Chem. B, 2024,12, 7122-7134
https://doi.org/10.1039/D4TB00223G
Enhancing cell adhesion in synthetic hydrogels via physical confinement of peptide-functionalized polymer clusters
A uniquely designed functional polymer cluster imparts cell adhesion characteristics to conventional synthetic hydrogels by being physically confined within the polymer network, without chemically modifying the hydrogel's polymer chains.
J. Mater. Chem. B, 2024,12, 7103-7112
https://doi.org/10.1039/D4TB00761A
Charge-reversal polymeric nanomodulators for ferroptosis-enhanced photodynamic therapy
The clinical application of photodynamic therapy (PDT) has some limitations including poor tumor targeting properties, a high reductive tumor microenvironment, and inefficient activation of single cell death machinery.
J. Mater. Chem. B, 2024,12, 7113-7121
https://doi.org/10.1039/D4TB00616J
Design and development of 3D printed shape memory triphasic polymer-ceramic bioactive scaffolds for bone tissue engineering
Scaffolds for bone tissue engineering require considerable mechanical strength to repair damaged bone defects.
J. Mater. Chem. B, 2024,12, 6886-6904
https://doi.org/10.1039/D4TB00785A
Tough and elastic hydrogels based on robust hydrophobicity-assisted metal ion coordination for flexible wearable devices
A hydrogel-based flexible sensor based on hydrophobicity-assisted metal ion coordination is reported for human movement monitoring and physiological signal detection.
J. Mater. Chem. B, 2024,12, 6605-6616
https://doi.org/10.1039/D4TB00933A
Supramolecular assembly of isomeric SN-38 prodrugs regulated by conjugation sites
By attaching hydrophilic OEG on different conjugation sites of SN38, isomeric self-assembling prodrugs were developed and self-assembled into giant nanotubes and filamentous assemblies, revealing the critical contribution of conjugation sites.
J. Mater. Chem. B, 2024,12, 6146-6154
https://doi.org/10.1039/D4TB00717D
Supramolecular DNA nanogels through host–guest interaction for targeted drug delivery
Supramolecular DNA nanogel was constructed by host–guest interaction from Y-DNA modified with methyl violet, dsDNA with azobenzene, and curcubit[8]uril. It possess stimuli responses, excellent biocompatibility and targeted drug transport ability.
J. Mater. Chem. B, 2024,12, 6137-6145
https://doi.org/10.1039/D4TB00853G
Fluorinated BPA derivatives enhanced 10B delivery in tumors
Fluorinated BPA derivatives exhibited improved 10B accumulation in tumors, and enhanced T/B and T/N ratios compared to clinical boron drug fructose-BPA (f-BPA).
J. Mater. Chem. B, 2024,12, 6128-6136
https://doi.org/10.1039/D4TB00846D
Radioactive hybrid semiconducting polymer nanoparticles for imaging-guided tri-modal therapy of breast cancer
Radioactive hybrid semiconducting polymer nanoparticles are developed for imaging-guided photothermal–photodynamic–sonodynamic tri-modal therapy of breast cancer.
J. Mater. Chem. B, 2024,12, 6091-6101
https://doi.org/10.1039/D4TB00834K
Comparative effectiveness of myocardial patches and intramyocardial injections in treating myocardial infarction with a MitoQ/hydrogel system
Schematic illustration of the comparative effectiveness of myocardial patches and intramyocardial injections in the treatment of myocardial infarction using a MitoQ/hydrogel system.
J. Mater. Chem. B, 2024,12, 5838-5847
https://doi.org/10.1039/D4TB00573B
Peptide nanovaccine conjugated via a retro-Diels–Alder reaction linker for overcoming the obstacle in lymph node penetration and eliciting robust cellular immunity
Nanovaccine conjugated via a retro-Diels–Alder reaction achieves lymph node deep penetration of antigens for enhancing vaccine efficacy.
J. Mater. Chem. B, 2024,12, 5848-5860
https://doi.org/10.1039/D4TB00674G
Copper peroxide nanodot-decorated gold nanostar/silica nanorod Janus nanostructure with NIR-II photothermal and acid-triggered hydroxyl radical generation properties for the effective treatment of wound infections
A multifunctional nanostructure with synergistic MPTT/CDT antibacterial activities was designed for the effective treatment of wound infections.
J. Mater. Chem. B, 2024,12, 5111-5127
https://doi.org/10.1039/D4TB00536H
Synthesis and characterization of a pH/temperature-dual responsive hydrogel with promising biocompatibility features for stimuli-responsive 5-FU delivery
The study focused on the fine refinement of PNIPAM-based materials, resulting in enhanced biocompatibility and drug loading for a smart hydrogel system with multi-responsive 5-FU release.
J. Mater. Chem. B, 2024,12, 5098-5110
https://doi.org/10.1039/D4TB00168K
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Drug delivery via a 3D electro-swellable conjugated polymer hydrogel
A glycolated polythiophene, p(g3T2), enables controlled drug loading/release of molecules with molecular weight of 800–6000 Da, due to large, reversible volume changes during electrochemical doping.
J. Mater. Chem. B, 2024,12, 4029-4038
https://doi.org/10.1039/D3TB02592F
Revelation of adhesive proteins affecting cellular contractility through reference-free traction force microscopy
Reference-free traction force microscopy with a regular microdot array was designed and proposed to reveal the effects of adhesive proteins on cellular contractility, cytoskeleton structure, morphogenesis and mechanotransduction.
J. Mater. Chem. B, 2024,12, 3249-3261
https://doi.org/10.1039/D4TB00065J
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Statistical optimization of hydrazone-crosslinked hyaluronic acid hydrogels for protein delivery
Design of experiments, a statistical optimization tool, was used to optimize the gelation time, compressive modulus, and stability of hydrazone-crosslinked hyaluronic acid hydrogels for controlled protein delivery.
J. Mater. Chem. B, 2024,12, 2523-2536
https://doi.org/10.1039/D3TB01588B
About this collection
Journal of Materials Chemistry B is pleased to present this themed collection highlighting the rising stars of materials chemistry research in 2023. This special collection showcases the very best work from materials chemists in the early stages of their independent career.
Each contributor was recommended by experts in their fields as carrying out work with the potential to influence future directions in materials chemistry with applications in biology and medicine. Congratulations to all the outstanding researchers featured!
See also:
Journal of Materials Chemistry A Emerging Investigators 2024
Journal of Materials Chemistry C Emerging Investigators 2024