Development of a by-product-free strategy for the synthesis of oxazoline from N-acetylglucosamine†
Sen
Zhou, 
a
Ma
Bo,
a
Feng
Tang,
b
Wenqiang
Liu,
a
Xin
Li,
a
Baoquan
Chen,
a
Shiying
Shang,
c
Wei
Huang,
b
Yaohao
Li
*a
and
Zhongping
Tan
*a
a
Ma
Bo,
a
Feng
Tang,
b
Wenqiang
Liu,
a
Xin
Li,
a
Baoquan
Chen,
a
Shiying
Shang,
c
Wei
Huang,
b
Yaohao
Li
*a
and
Zhongping
Tan
*a
Abstract
This study focused on the CDMBI-mediated synthesis of GlcNAc oxazoline. Through our research, we uncovered and characterized a previously unreported by-product. We proposed a mechanism for its formation and developed a new strategy to prevent its occurrence. These findings represent an important step towards gaining a deeper understanding of this reaction and may provide a new avenue for optimizing the oxazoline synthesis.
- This article is part of the themed collection: New Journal of Chemistry HOT Articles
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