Themed collection Editor’s Choice: Recent breakthroughs in nanobiotechnology

This Minireview highlights and discusses the critical role of biological interfacing in constructing nanoplasmonic sensing platforms for biointerfacial science applications.

This review discusses the main nanomaterial-induced immunomodulatory mechanisms and how insights into these mechanisms lead to new therapeutic applications.

CRISPR-Cas9, the breakthrough genome-editing technology, has emerged as a promising tool to prevent and cure various diseases.

This review highlights the importance of the dimensionality and surface interactions of 2D materials with examples of recent biosensing and biomedical applications.

Iron labeled CTCs home to previously established mammary fat pad tumours and can be visualized using magnetic particle imaging and magnetic resonance imaging.

Unveiling the nanomechanical stability of the novel coronavirus (SARS-CoV-2) spike protein

a) Diagram depicting the preparation of drug delivery system of PLGA-lysoGM1/DOX micelles. b) Schematic illustration of micelles elicited antitumor. c) Micelles cross BBB via micropinocytosis and autophagy/lysosomal pathways.

DNA-free single-molecule cut-and-paste enables spatially controlled assembly of labelled biomolecules into well-defined geometries (e.g. a star) with nanometre precision.

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the cause of the coronavirus disease that began in 2019 (COVID-19), has been responsible for 1.4 million deaths worldwide as of 13 November 2020.

The outer membrane (OM) of Gram-negative bacteria is a complex asymmetric bilayer containing lipids, lipopolysaccharides (LPS) and proteins.

Schematic representation of the machine cycle for DNA modification on an origami-based enzyme nano-factory.

An enzyme-mediated universal fluorescent biosensor template for rapid detection of pathogens was developed based on the strategy of a three-dimensional (3D) DNA walker and catalyzed hairpin assembly (CHA) reaction.

Nanoscale flow cytometry permits analysis of small particles in unpurified plasma and supports identification and quantitation of different particle populations.

Protein-inspired nanopores with hydrophobic constriction regions have previously been shown to offer some promise for DNA sequencing.

Switching microglia from a disease exacerbating, ‘pro-inflammatory’ state into a neuroprotective, ‘anti-inflammatory’ phenotype is a promising strategy for addressing multiple neurodegenerative diseases.

Inspired by the self-assembly approach, in this work, the chromogen, 3,3′,5,5′-tetramethylbenzidine (TMB), was successfully co-precipitated in aqueous solution to form collective nanoparticles (NPs) of signal molecules (TMB-NPs).

Intracluster bonds in hyperbranched DNA polymers prevent percolation transition.

Isolation of anti-N-cadherin DNA aptamers and high-efficiency capture of circulating tumor cells using dual aptamers targeting EpCAM and N-cadherin.

The reactive oxygen species (ROS)-mediated anti-cancer therapy that shows the advantages of tumor specificity, high curative effect, and less toxic side-effects has powerful potential for cancer treatment.

The combination of magnetic nanoparticles and thermoresponsive polymers to build multifunctional nanogels represents an appealing strategy for the development of theranostic probes.

Herein, we identify the long-term miRNA expression changes induced by a low dose of AuNPs, providing a systems-level perspective of these changes. The miRNA dysregulation is mostly implicated in the cellular response to the stress caused by AuNPs.

Supramolecular antibiotics: a reactive supramolecular disassembly approach ensures the narrow delivery of broad-spectrum antibiotics to selectively target pathogenic bacterial population.

A novel strategy for combating bacteria is proposed based on MnO₂@Ag micromotors. Due to synergistic reaction of MnO₂ and Ag, rapid movement was realized and an enhanced E. coli death was achieved by coupling intense motion with Ag⁺ sterilization.

We present the study of the nanoprobes' diffusion in the extracellular matrix (ECM) of multicellular spheroids.

Current control of pathogenic bacteria at all biomaterial interfaces is poorly attuned to a broad range of disease-causing pathogens.

We show that hydrogel-mediated combination therapy induces a synergistic effect on tumor regression.

Combining the technologies of encapsulation of GPCRs in SMA lipid particles with fluorescence correlation spectroscopy provides a versatile characterisation platform.

Exploitation of the nanoparticle protein corona to identify proteomic fingerprints in blood that differentiate non-bacterial systemic inflammation from sepsis.

Method to measure the viscoelastic properties of a living cell by AFM-based force–distance curves.

Introducing a disulfide bridge within monovalent streptavidin's N-terminal β-sheet structure significantly increases the mechanical stability of the biotin/streptavidin complex.

Detecting small variations in the levels of IL-6 is crucial for the early diagnosis of sepsis.

Although DNA recognition has been achieved using numerous biosensors with various sensing probes, the utilization of bio-interaction between DNA and biomolecules has seldom been reported in universal DNA detection.

The UL27 gene of Human simplex virus-1 has been identified through hybridization to superparamagnetic particles and identification on a microfabricated magnet array with integrated optical detector.

Bioreducible nanoparticles were engineered for safe and effective systemic siRNA delivery, including crossing the blood–brain barrier to achieve in vivo gene silencing in an orthotopic glioblastoma mouse model.

Co-block polymer surfaces provide a platform on which to visualize DNA–protein interactions by atomic force microscopy at nanometre resolution.

For investigating Alzheimer's disease mechanisms, high-speed atomic force microscopy is a proper tool to monitor the interactions between toxic peptides and lipid model membranes.

Membrane partition and remodeling play a key role in numerous cell mechanisms, especially in viral replication cycles where viruses subvert the plasma membrane to enter and escape from the host cell.

Label free nanomechanical miRNA detection from biological samples utilising cantilever arrays in an automated diagnostic platform.

We present a fast, label-free, QCM-based methodology for the screening of accessible protein recognition epitopes on NP biological surface.