Themed collection Exploring multivalent carbohydrate-protein interactions with chemical ligations

13 items
Review Article

Serum antibody screening using glycan arrays

Glycan microarrays provide a high-throughput platform to rapidly interrogate serum anti-glycan antibodies, identify new biomarkers for a variety of conditions, and analyze the immune system's response to vaccines and other treatments.

Graphical abstract: Serum antibody screening using glycan arrays
Open Access Review Article

Glycomimetics for the inhibition and modulation of lectins

Carbohydrates are essential mediators of many processes in health and disease. The development of glycomimetics as inhibitors and modulators of their lectin receptors has been a success story with numerous molecules reaching clinical stages.

Graphical abstract: Glycomimetics for the inhibition and modulation of lectins
Review Article

Carrier diversity and chemical ligations in the toolbox for designing tumor-associated carbohydrate antigens (TACAs) as synthetic vaccine candidates

This review highlights the recent development in the use of carriers of increasing simplicities and versatile chemical ligation processes leading to synthetic vaccine candidates against tumor-associated carbohydrate antigens (TACAs).

Graphical abstract: Carrier diversity and chemical ligations in the toolbox for designing tumor-associated carbohydrate antigens (TACAs) as synthetic vaccine candidates
Open Access Review Article

Glycopolymers against pathogen infection

Glycomacromolecules show significant potential as antimicrobials. We highlight recent studies on their performance in hindering host cell entry and biofilm formation, and their potential as drug delivery and diagnostic agents.

Graphical abstract: Glycopolymers against pathogen infection
Open Access Review Article

Exploring multivalent carbohydrate–protein interactions by NMR

Nuclear Magnetic Resonance (NMR) has been widely employed to assess diverse features of glycan–protein molecular recognition events.

Graphical abstract: Exploring multivalent carbohydrate–protein interactions by NMR
Open Access Review Article

Targeted delivery of oligonucleotides using multivalent protein–carbohydrate interactions

This review traces the development of targeted delivery of nucleic acids to liver cells using multivalent carbohydrate ligands.

Graphical abstract: Targeted delivery of oligonucleotides using multivalent protein–carbohydrate interactions
Open Access Review Article

Multivalent glycosystems for human lectins

This review summarises major contributions based on carbohydrate multivalent systems to study their interaction with human lectins.

Graphical abstract: Multivalent glycosystems for human lectins
Review Article

Metabolic glycoengineering – exploring glycosylation with bioorthogonal chemistry

Metabolic glycoengineering in combination with bioorthogonal chemistry provides a means to study and exploit the biological functions of glycans.

Graphical abstract: Metabolic glycoengineering – exploring glycosylation with bioorthogonal chemistry
Open Access Review Article

Carbon-based glyco-nanoplatforms: towards the next generation of glycan-based multivalent probes

This review highlights the recent achievements in the field of carbon-based multivalent glyco-nanoplatforms with biological applications.

Graphical abstract: Carbon-based glyco-nanoplatforms: towards the next generation of glycan-based multivalent probes
Open Access Review Article

Multivalent glycocyclopeptides: conjugation methods and biological applications

In this review, we describe the conjugation methods used to construct multivalent glycocyclopeptides and their utilization for applications in glycoscience.

Graphical abstract: Multivalent glycocyclopeptides: conjugation methods and biological applications
Review Article

Glycan microarrays from construction to applications

This article summarizes the preparation of glycan probes, the construction of glycan microarrays and their applications for biological and biomedical research.

Graphical abstract: Glycan microarrays from construction to applications
Open Access Tutorial Review

Small lectin ligands as a basis for applications in glycoscience and glycomedicine

Understanding lectin–ligand interaction inspires synthesis of glycomimetic and glycocluster ligands for applications.

Graphical abstract: Small lectin ligands as a basis for applications in glycoscience and glycomedicine
Tutorial Review

Peptide mimotopes to emulate carbohydrates

This review describes the design and preparation of peptide mimotopes, their structural and functional mimicry properties, and their advantages over that of glycan ligands in developing a therapeutic strategy to treat glycan-related diseases.

Graphical abstract: Peptide mimotopes to emulate carbohydrates
13 items

About this collection

Carbohydrate-protein interactions play central roles in biology. The utilization of ligation chemistry has revolutionized this field by providing powerful synthetic tools to understand and manipulate these interactions and develop a diversity of diagnostic and therapeutic applications. Following a previous themed issue on “Multivalent Scaffolds in Glycosciences” published in Chemical Society Reviews in 2013, we aim at giving an extended overview of the recent progress in this field, with a special focus on biological/disease applications. Different key aspects are covered, including antiadhesive glycoarchitectures, metabolic cell glycoengineering, synthetic vaccines/immunomodulators, biophysical tools and glycoarrays. This themed issue aims to represent a standard reference for the large scientific community involved in glycosciences.


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