RSC Advances
Bioanalytical articles published in the last
6 months
Automatic microdispenser-integrated multiplex enzyme-linked immunosorbent assay device with autonomously driven centrifugal microfluidic system
A design theory for an autonomously driven dispenser was established. The multiplexed ELISA device was integrated with the dispenser and CLOCK circuits, and successfully prepared a calibration curve of mouse IgG by rotating at a constant speed.
RSC Adv., 2024,14, 13827-13836
https://doi.org/10.1039/D4RA02656J
Colorimetric detection of Hg2+ based on the enhanced oxidase-mimic activity of CuO/Au@Cu3(BTC)2 triggered by Hg2+
A colorimetric method was designed for Hg2+ detection based on the enhanced oxidase-mimic activity of CuO/Au@Cu3(BTC)2.
RSC Adv., 2024,14, 13808-13816
https://doi.org/10.1039/D4RA01953A
Selection, characterization, and biosensing applications of DNA aptamers targeting cyanotoxin BMAA
Scientists have established a connection between environmental exposure to toxins like β-N-methylamino-L-alanine (BMAA) and a heightened risk of neurodegenerative disorders.
RSC Adv., 2024,14, 13787-13800
https://doi.org/10.1039/D4RA02384F
Rapid and quantitative detection of DNA hybridization using a simplified Fabry–Perot interferometric biosensor
The simple-structured Fabry–Perot interferometric biosensor is capable of rapid and quantitative detection of DNA hybridization.
RSC Adv., 2024,14, 13367-13373
https://doi.org/10.1039/D4RA01390E
A multi-channel microfluidic platform based on human flavin-containing monooxygenase 3 for personalised medicine
A microfluidic platform with immobilized human flavin-containing monooxygenase for high-throughput screening of drugs with relevance to personalised medicine.
RSC Adv., 2024,14, 13209-13217
https://doi.org/10.1039/D4RA01516A
Rational design of a lysosome-targeted fluorescent probe for monitoring the generation of hydroxyl radicals in ferroptosis pathways
A novel hydrocyanine-based turn-on fluorescence probe HCy-Lyso, with excellent lysosome-targeting ability and ˙OH-responsive efficiency, has been applied for monitoring the variation in lysosomal ˙OH levels during ferroptosis.
RSC Adv., 2024,14, 12864-12872
https://doi.org/10.1039/D4RA00562G
Application of cold-adapted microbial agents in soil contaminate remediation: biodegradation mechanisms, case studies, and safety assessments
Analyzed the microorganisms cold-adapted mechanism, and summarized the degradation pathway of nitro-aromatic compounds. Evaluated safety of microbial agents according to the existing application restoration cases under freeze-thaw cycles condition.
RSC Adv., 2024,14, 12720-12734
https://doi.org/10.1039/D4RA01510J
Synthesis and characterization of a nanostructure conductive copolymer based on polyaniline and polylactic acid as an effective substrate in proteins impedimetric biosensing
Despite of all the developments in DNA microarray technology, there is not sufficient knowledge about protein abundance or their function in processes such as proteolysis, phosphorylation.
RSC Adv., 2024,14, 12600-12611
https://doi.org/10.1039/D4RA01061B
Label-free detection of Aβ-42: a liquid crystal droplet approach for Alzheimer's disease diagnosis
This study introduces a biosensor based on liquid crystals (LC) designed to detect the Aβ-42 biomarker, commonly associated with Alzheimer's disease.
RSC Adv., 2024,14, 12107-12118
https://doi.org/10.1039/D4RA00615A
Detection of SARS-CoV-2 N protein using AgNPs-modified aligned silicon nanowires BioSERS chip
A sensitive and selective bioSERS chip was developed for the detection of nucleocapsid protein from SARS-CoV-2 virus, applied to sense the N protein in human blood serum.
RSC Adv., 2024,14, 12071-12080
https://doi.org/10.1039/D4RA00267A
Skin emitted volatiles analysis for noninvasive diagnosis: the current advances in sample preparation techniques for biomedical application
Analytical technique for monitoring skin-emitted metabolites to diagnose diseases.
RSC Adv., 2024,14, 12009-12020
https://doi.org/10.1039/D4RA01579G
Electrochemical sensing of B-complex vitamins: current challenges and future prospects with microfluidic integration
Vitamins are crucial micronutrients found in limited quantities in food, living organisms, and soil.
RSC Adv., 2024,14, 10331-10347
https://doi.org/10.1039/D4RA00555D
Synthesis of Os@ZIF-8 nanocomposites with enhanced peroxidase-like activity for detection of Hg2+
Preparation of Os@ZIF-8 NCs and detection of Hg2+ concentration.
RSC Adv., 2024,14, 9996-10003
https://doi.org/10.1039/D3RA08723A
Recent advancements in the specific determination of carcinoembryonic antigens using MOF-based immunosensors
Carcinoembryonic antigens (CEAs) are prominent cancer biomarkers that enable the early detection of numerous cancers.
RSC Adv., 2024,14, 9571-9586
https://doi.org/10.1039/D3RA07059J
Probing the influence of crosslinkers on the properties, response, and degradation of enzymatic hydrogels for electrochemical glucose biosensing through fluorescence analysis
The combination of microscopy, spectroscopy, and electrochemical techniques reveals crosslinker effects in enzymatic hydrogels and allows probing for a possible degradation mechanism of these gels.
RSC Adv., 2024,14, 9514-9528
https://doi.org/10.1039/D4RA00265B
Development of electrochemical sensors for quick detection of environmental (soil and water) NPK ions
When a plant shows deficiency syndromes, sometimes it becomes too late for the farmer to apply fertilizer, as most rely on checking plant leaves to assess their nutrition level. Electrochemical sensors can bring revolution here. Other pollutants (NPK) can also be determined using these sensors.
RSC Adv., 2024,14, 9137-9158
https://doi.org/10.1039/D4RA00034J
Ultrasensitive colorimetric detection of creatinine via its dual binding affinity for silver nanoparticles and silver ions
Creatinine detection via dual binding affinity for silver nanoparticles and silver ions.
RSC Adv., 2024,14, 9114-9121
https://doi.org/10.1039/D3RA08736K
Real-time fluorescent monitoring of phase I xenobiotic-metabolizing enzymes
Applications of chemosensors of phase I metabolizing enzymes.
RSC Adv., 2024,14, 8837-8870
https://doi.org/10.1039/D4RA00127C
An innovative transportable immune device for the recognition of α-synuclein using KCC-1-nPr-CS2 modified silver nano-ink: integration of pen-on-paper technology with biosensing toward early-stage diagnosis of Parkinson's disease
Parkinson's disease (PD), the second most frequent neurodegenerative illness, is a neurological ailment that produces unintentional or uncontrolled body movements, which should be diagnosed in its early stages to hinder the progression.
RSC Adv., 2024,14, 8810-8818
https://doi.org/10.1039/D3RA07058A
A prototype of ultrasensitive time-resolved fluoroimmunoassay for the quantitation of lead in plasma using a fluorescence-enhanced europium chelate label for the detection system
This study describes the development and validation of a prototype time-resolved fluoroimmunoassay (TRFIA) for the quantification of lead in plasma. The assay is valuable for controlling the exposure of humans to potential lead toxicities.
RSC Adv., 2024,14, 8671-8683
https://doi.org/10.1039/D3RA07673C
Optical dِِِِiscrimination of histamine and ethylenediamine in meat samples using a colorimetric affordable test strip (CATS): introducing a novel lab-on paper sensing strategy for low-cost ensuring food safety by rapid and accurate monitoring of biogenic amines
A novel colorimetric affordable test strip was developed for the colorimetric and naked-eye detection of two biogenic amines.
RSC Adv., 2024,14, 8602-8614
https://doi.org/10.1039/D4RA00101J
Synergistic acceleration of machine learning and molecular docking for prostate-specific antigen ligand design
By employing a million-level virtual screening to obtain potential PSA compounds and effectively guiding the synthesis using machine learning methods, we obtained lead compounds that exhibited significantly improved binding affinity for PSA.
RSC Adv., 2024,14, 8240-8250
https://doi.org/10.1039/D3RA08550C
A novel ultrasensitive chemiluminescence enzyme immunoassay by employment of a signal enhancement of horseradish peroxidase-luminol-hydrogen peroxide reaction for the quantitation of atezolizumab, a monoclonal antibody used for cancer immunotherapy
An ultrasensitive non-competitive chemiluminescence enzyme immunoassay (CLEIA) for the quantification of atezolizumab (ATZ), a monoclonal antibody used for treatment of different types of cancer. The assay employed a new chemiluminescence-enhancement reaction for detection.
RSC Adv., 2024,14, 8167-8177
https://doi.org/10.1039/D4RA00202D
Aqueous alkaline phosphate facilitates the non-exchangeable deuteration of peptides and proteins
The incorporation of deuterium into peptides and proteins holds broad applications across various fields, such as drug development and structural characterization.
RSC Adv., 2024,14, 8075-8080
https://doi.org/10.1039/D3RA08636D
Enhanced sensitivity in electrochemical detection of ochratoxin A within food samples using ferrocene- and aptamer-tethered gold nanoparticles on disposable electrodes
A highly sensitive yet simple-to-preare electrochemical aptasensor was designed for OTA biosensing in real samples. Ferrocene was introduced as a transducing agent, eliminating the need for a solution-based approach.
RSC Adv., 2024,14, 8007-8015
https://doi.org/10.1039/D3RA08567H
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