RSC Advances  

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Bioanalytical articles published in the last 6 months

70 items - Showing page 1 of 3
Open Access Paper

Automatic microdispenser-integrated multiplex enzyme-linked immunosorbent assay device with autonomously driven centrifugal microfluidic system

A design theory for an autonomously driven dispenser was established. The multiplexed ELISA device was integrated with the dispenser and CLOCK circuits, and successfully prepared a calibration curve of mouse IgG by rotating at a constant speed.

Graphical abstract: Automatic microdispenser-integrated multiplex enzyme-linked immunosorbent assay device with autonomously driven centrifugal microfluidic system
Open Access Paper

Colorimetric detection of Hg2+ based on the enhanced oxidase-mimic activity of CuO/Au@Cu3(BTC)2 triggered by Hg2+

A colorimetric method was designed for Hg2+ detection based on the enhanced oxidase-mimic activity of CuO/Au@Cu3(BTC)2.

Graphical abstract: Colorimetric detection of Hg2+ based on the enhanced oxidase-mimic activity of CuO/Au@Cu3(BTC)2 triggered by Hg2+
Open Access Paper

Selection, characterization, and biosensing applications of DNA aptamers targeting cyanotoxin BMAA

Scientists have established a connection between environmental exposure to toxins like β-N-methylamino-L-alanine (BMAA) and a heightened risk of neurodegenerative disorders.

Graphical abstract: Selection, characterization, and biosensing applications of DNA aptamers targeting cyanotoxin BMAA
Open Access Paper

Rapid and quantitative detection of DNA hybridization using a simplified Fabry–Perot interferometric biosensor

The simple-structured Fabry–Perot interferometric biosensor is capable of rapid and quantitative detection of DNA hybridization.

Graphical abstract: Rapid and quantitative detection of DNA hybridization using a simplified Fabry–Perot interferometric biosensor
Open Access Paper

A multi-channel microfluidic platform based on human flavin-containing monooxygenase 3 for personalised medicine

A microfluidic platform with immobilized human flavin-containing monooxygenase for high-throughput screening of drugs with relevance to personalised medicine.

Graphical abstract: A multi-channel microfluidic platform based on human flavin-containing monooxygenase 3 for personalised medicine
Open Access Paper

Rational design of a lysosome-targeted fluorescent probe for monitoring the generation of hydroxyl radicals in ferroptosis pathways

A novel hydrocyanine-based turn-on fluorescence probe HCy-Lyso, with excellent lysosome-targeting ability and ˙OH-responsive efficiency, has been applied for monitoring the variation in lysosomal ˙OH levels during ferroptosis.

Graphical abstract: Rational design of a lysosome-targeted fluorescent probe for monitoring the generation of hydroxyl radicals in ferroptosis pathways
Open Access Review Article

Application of cold-adapted microbial agents in soil contaminate remediation: biodegradation mechanisms, case studies, and safety assessments

Analyzed the microorganisms cold-adapted mechanism, and summarized the degradation pathway of nitro-aromatic compounds. Evaluated safety of microbial agents according to the existing application restoration cases under freeze-thaw cycles condition.

Graphical abstract: Application of cold-adapted microbial agents in soil contaminate remediation: biodegradation mechanisms, case studies, and safety assessments
Open Access Paper

Synthesis and characterization of a nanostructure conductive copolymer based on polyaniline and polylactic acid as an effective substrate in proteins impedimetric biosensing

Despite of all the developments in DNA microarray technology, there is not sufficient knowledge about protein abundance or their function in processes such as proteolysis, phosphorylation.

Graphical abstract: Synthesis and characterization of a nanostructure conductive copolymer based on polyaniline and polylactic acid as an effective substrate in proteins impedimetric biosensing
Open Access Paper

Label-free detection of Aβ-42: a liquid crystal droplet approach for Alzheimer's disease diagnosis

This study introduces a biosensor based on liquid crystals (LC) designed to detect the Aβ-42 biomarker, commonly associated with Alzheimer's disease.

Graphical abstract: Label-free detection of Aβ-42: a liquid crystal droplet approach for Alzheimer's disease diagnosis
Open Access Paper

Detection of SARS-CoV-2 N protein using AgNPs-modified aligned silicon nanowires BioSERS chip

A sensitive and selective bioSERS chip was developed for the detection of nucleocapsid protein from SARS-CoV-2 virus, applied to sense the N protein in human blood serum.

Graphical abstract: Detection of SARS-CoV-2 N protein using AgNPs-modified aligned silicon nanowires BioSERS chip
Open Access Review Article

Skin emitted volatiles analysis for noninvasive diagnosis: the current advances in sample preparation techniques for biomedical application

Analytical technique for monitoring skin-emitted metabolites to diagnose diseases.

Graphical abstract: Skin emitted volatiles analysis for noninvasive diagnosis: the current advances in sample preparation techniques for biomedical application
Open Access Review Article

Electrochemical sensing of B-complex vitamins: current challenges and future prospects with microfluidic integration

Vitamins are crucial micronutrients found in limited quantities in food, living organisms, and soil.

Graphical abstract: Electrochemical sensing of B-complex vitamins: current challenges and future prospects with microfluidic integration
From the themed collection: 2024 Reviews in RSC Advances
Open Access Paper

Synthesis of Os@ZIF-8 nanocomposites with enhanced peroxidase-like activity for detection of Hg2+

Preparation of Os@ZIF-8 NCs and detection of Hg2+ concentration.

Graphical abstract: Synthesis of Os@ZIF-8 nanocomposites with enhanced peroxidase-like activity for detection of Hg2+
Open Access Review Article

Recent advancements in the specific determination of carcinoembryonic antigens using MOF-based immunosensors

Carcinoembryonic antigens (CEAs) are prominent cancer biomarkers that enable the early detection of numerous cancers.

Graphical abstract: Recent advancements in the specific determination of carcinoembryonic antigens using MOF-based immunosensors
From the themed collection: 2024 Reviews in RSC Advances
Open Access Paper

Probing the influence of crosslinkers on the properties, response, and degradation of enzymatic hydrogels for electrochemical glucose biosensing through fluorescence analysis

The combination of microscopy, spectroscopy, and electrochemical techniques reveals crosslinker effects in enzymatic hydrogels and allows probing for a possible degradation mechanism of these gels.

Graphical abstract: Probing the influence of crosslinkers on the properties, response, and degradation of enzymatic hydrogels for electrochemical glucose biosensing through fluorescence analysis
Open Access Review Article

Development of electrochemical sensors for quick detection of environmental (soil and water) NPK ions

When a plant shows deficiency syndromes, sometimes it becomes too late for the farmer to apply fertilizer, as most rely on checking plant leaves to assess their nutrition level. Electrochemical sensors can bring revolution here. Other pollutants (NPK) can also be determined using these sensors.

Graphical abstract: Development of electrochemical sensors for quick detection of environmental (soil and water) NPK ions
From the themed collection: 2024 Reviews in RSC Advances
Open Access Paper

Ultrasensitive colorimetric detection of creatinine via its dual binding affinity for silver nanoparticles and silver ions

Creatinine detection via dual binding affinity for silver nanoparticles and silver ions.

Graphical abstract: Ultrasensitive colorimetric detection of creatinine via its dual binding affinity for silver nanoparticles and silver ions
Open Access Review Article

Real-time fluorescent monitoring of phase I xenobiotic-metabolizing enzymes

Applications of chemosensors of phase I metabolizing enzymes.

Graphical abstract: Real-time fluorescent monitoring of phase I xenobiotic-metabolizing enzymes
From the themed collection: 2024 Reviews in RSC Advances
Open Access Paper

An innovative transportable immune device for the recognition of α-synuclein using KCC-1-nPr-CS2 modified silver nano-ink: integration of pen-on-paper technology with biosensing toward early-stage diagnosis of Parkinson's disease

Parkinson's disease (PD), the second most frequent neurodegenerative illness, is a neurological ailment that produces unintentional or uncontrolled body movements, which should be diagnosed in its early stages to hinder the progression.

Graphical abstract: An innovative transportable immune device for the recognition of α-synuclein using KCC-1-nPr-CS2 modified silver nano-ink: integration of pen-on-paper technology with biosensing toward early-stage diagnosis of Parkinson's disease
Open Access Paper

A prototype of ultrasensitive time-resolved fluoroimmunoassay for the quantitation of lead in plasma using a fluorescence-enhanced europium chelate label for the detection system

This study describes the development and validation of a prototype time-resolved fluoroimmunoassay (TRFIA) for the quantification of lead in plasma. The assay is valuable for controlling the exposure of humans to potential lead toxicities.

Graphical abstract: A prototype of ultrasensitive time-resolved fluoroimmunoassay for the quantitation of lead in plasma using a fluorescence-enhanced europium chelate label for the detection system
Open Access Paper

Optical dِِِِiscrimination of histamine and ethylenediamine in meat samples using a colorimetric affordable test strip (CATS): introducing a novel lab-on paper sensing strategy for low-cost ensuring food safety by rapid and accurate monitoring of biogenic amines

A novel colorimetric affordable test strip was developed for the colorimetric and naked-eye detection of two biogenic amines.

Graphical abstract: Optical dِِِِiscrimination of histamine and ethylenediamine in meat samples using a colorimetric affordable test strip (CATS): introducing a novel lab-on paper sensing strategy for low-cost ensuring food safety by rapid and accurate monitoring of biogenic amines
Open Access Paper

Synergistic acceleration of machine learning and molecular docking for prostate-specific antigen ligand design

By employing a million-level virtual screening to obtain potential PSA compounds and effectively guiding the synthesis using machine learning methods, we obtained lead compounds that exhibited significantly improved binding affinity for PSA.

Graphical abstract: Synergistic acceleration of machine learning and molecular docking for prostate-specific antigen ligand design
Open Access Paper

A novel ultrasensitive chemiluminescence enzyme immunoassay by employment of a signal enhancement of horseradish peroxidase-luminol-hydrogen peroxide reaction for the quantitation of atezolizumab, a monoclonal antibody used for cancer immunotherapy

An ultrasensitive non-competitive chemiluminescence enzyme immunoassay (CLEIA) for the quantification of atezolizumab (ATZ), a monoclonal antibody used for treatment of different types of cancer. The assay employed a new chemiluminescence-enhancement reaction for detection.

Graphical abstract: A novel ultrasensitive chemiluminescence enzyme immunoassay by employment of a signal enhancement of horseradish peroxidase-luminol-hydrogen peroxide reaction for the quantitation of atezolizumab, a monoclonal antibody used for cancer immunotherapy
Open Access Paper

Aqueous alkaline phosphate facilitates the non-exchangeable deuteration of peptides and proteins

The incorporation of deuterium into peptides and proteins holds broad applications across various fields, such as drug development and structural characterization.

Graphical abstract: Aqueous alkaline phosphate facilitates the non-exchangeable deuteration of peptides and proteins
Open Access Paper

Enhanced sensitivity in electrochemical detection of ochratoxin A within food samples using ferrocene- and aptamer-tethered gold nanoparticles on disposable electrodes

A highly sensitive yet simple-to-preare electrochemical aptasensor was designed for OTA biosensing in real samples. Ferrocene was introduced as a transducing agent, eliminating the need for a solution-based approach.

Graphical abstract: Enhanced sensitivity in electrochemical detection of ochratoxin A within food samples using ferrocene- and aptamer-tethered gold nanoparticles on disposable electrodes
70 items - Showing page 1 of 3

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