RSC Advances  

In this work, we have described the use of α-bromonitrostyrenes in the synthesis of a wide variety of carbocyclic and heterocyclic compounds under organocatalysis, metal catalysis, and base-catalysis systems as well as catalyst-free reactions.

The organocatalytic Morita–Baylis–Hillman (MBH) reaction, one of the most significant carbon–carbon bond formations involves the addition of α,β-unsaturated carbonyl compounds to activated alkenes to give α-methylene-β-hydroxycarbonyl compounds.

A base-mediated, three-component synthesis of symmetric and unsymmetric pyran-fused biscoumarins via the coupling of 4-hydroxycoumarin with 4-chloro-3-formylcoumarin in ethanol is reported.

A versatile photoredox-catalyzed three-component sulfonylation of diaryliodonium salts with DABSO and silyl enolates involving the insertion of SO₂ for the synthesis of β-keto sulfones was developed.

The dihydrobenzofuran scaffolds demonstrate a wide range of biological activities. Several transition metals have been employed as catalysts for the efficacious synthesis of these structurally important frameworks.

A Ts₂O promoted deoxygenative C2-dithiocarbamation of quinoline N-oxides with CS₂ and amines toward various quinoline-dithiocarbamates under transition-metal free conditions was developed.

The synthesis of amines through N-alkylation is particularly attractive.

2-N-Substituted indenones, cyclopentenones or 4-carbonyl oxazoles are prepared from 5-acylated N-fluoroalkyl substituted 1,2,3-triazoles and Lewis acids.

A novel protocol for introducing an acetoxy functional group selectively on the ortho aryl sp² carbon of 2-aryloxyquinoline-3-carbaldehydes in good yields with good functional group tolerance using a palladium catalyst was developed for the first time.

An efficient and mild approach has been developed for the regio-selective direct C3 halogenation of pyrazolo[1,5-a]pyrimidines employing readily available potassium halide salts and a hypervalent iodine(III) reagent at ambient temperature.

Epoxides are oxygen containing three-membered heterocycles which can undergo ring opening reactions. These reactions have been significantly employed in the synthesis of alkaloids and terpenoids-based natural products.

This work describes the manganese catalyzed direct coupling of nitriles with alcohols with assistance of a set of simple and new imidazole-based N,N-bidentate ligands.

Nickel-catalyzed cross-electrophile coupling of cyclopropyl ketones and alkyl chlorides. High reactivity and selectivity can be achieved with sodium iodide as a cocatalyst that generates a low concentration of alkyl iodide via halide exchange.

A mild, efficient and convenient procedure for the acetylation of alcohols with EtOAc as acetyl source and solvent mediated by KOH was reported.

An electrochemical approach to access seleno-benzazepines through an oxidative radical cascade cyclization of dienes with diselenides under metal-free, external oxidant-free and base-free conditions.

Oxamic acids where shown to add to imines, providing a broad range of α-aminoacid amides in generally good yields.

An overview on the mechanism of Pseudomonas aeruginosa PAO1 biofilm inhibition by Suzuki–Miyaura coupled flavonols.

Bicyclic guanidines are utilized in organic synthesis as base catalysts or reagents.

Using a quinone monoacetal as the oxidant and DABCO as the base, we report the one-step synthesis of α-aryl-substituted pyrrolidines from pyrrolidine. The reaction of pyrrolidine and quinone monoacetal in 2,2,2-trifluoroethanol afforded octahydro-dipyrroloquinoline in high yield.

This review article highlights the use of Betti base derivatives in transformation reactions for synthesizing organic compounds, particularly heterocyclic molecules, and investigation into their pharmacological properties.

Through a stereoscopic design strategy, U-shaped N-heteroacene was synthesized, and shows regular and incompletely closed pores within the crystal structure.

Spirooxindolopyrrolidines were synthesized in quantitative yield through cycloaddition strategy. Compounds exhibited significant anti-tubercular activity and molecular docking studies of the compound is well correlates with in vitro findings.

PBIs were synthesized from the reaction of perylene bisanhydrides and primary amines in imidazole as solvent. Maleimide, anthraquinone or ferrocene were bonded to the side chain and the S-trityl group was replaced by imidazole in S-trityl cysteine.

Purine nucleoside ester is one of the derivatives of purine nucleoside, which has antiviral and anticancer activities.