RSC Advances  

Desulfurative functionalization of organosulfur compounds to form various carbon–carbon and carbon–heteroatom bonds has become established as a powerful tool in organic chemistry.

A chemoselective one-pot synthesis of indole–pyrrole hybrids has been developed. The new hybrids were phenotypically screened for efficacy against L. infantum promastigotes. Compound 3d was the most active with IC₅₀ = 9.6 μM and a selectivity index of 5.

A highly efficient method for the direct construction of amide bonds via a selective cleavage of C–H and CC bonds in indole structures using an iodine-promoted approach was developed.

A CPA-catalyzed switchable divergent synthesis of chiral indolenines/indolines via the CADA of 2,3-disubstituted indoles has been described. The post-processing conditions played a key role for the structure switch of the final products.

Friedel–Crafts benzylation/alkylation using benzylic alcohols and aryl carbonyls as proelectrophiles is achieved using borane-ammonia and TiCl₄.

Significant advancements have been made in catalytic asymmetric α-C–H bond functionalization of ethers via carbenoid insertion over the past decade.

A one-pot pseudo three-component cascade reaction for the preparation of 1,3,4-selenadiazole from aldehydes, hydrazine and elemental selenium is demonstrated here using the catalytic system consisting of KI and K₂S₂O₈ in DMSO.

In this work, we have described the use of α-bromonitrostyrenes in the synthesis of a wide variety of carbocyclic and heterocyclic compounds under organocatalysis, metal catalysis, and base-catalysis systems as well as catalyst-free reactions.

The double decarboxylative coupling reaction between two (similar or different) molecules of carboxylic acids is an emerging area that has gained considerable attention as a new avenue for forging carbon–carbon bonds.

The organocatalytic Morita–Baylis–Hillman (MBH) reaction, one of the most significant carbon–carbon bond formations involves the addition of α,β-unsaturated carbonyl compounds to activated alkenes to give α-methylene-β-hydroxycarbonyl compounds.

A base-mediated, three-component synthesis of symmetric and unsymmetric pyran-fused biscoumarins via the coupling of 4-hydroxycoumarin with 4-chloro-3-formylcoumarin in ethanol is reported.

A versatile photoredox-catalyzed three-component sulfonylation of diaryliodonium salts with DABSO and silyl enolates involving the insertion of SO₂ for the synthesis of β-keto sulfones was developed.

The dihydrobenzofuran scaffolds demonstrate a wide range of biological activities. Several transition metals have been employed as catalysts for the efficacious synthesis of these structurally important frameworks.

A Ts₂O promoted deoxygenative C2-dithiocarbamation of quinoline N-oxides with CS₂ and amines toward various quinoline-dithiocarbamates under transition-metal free conditions was developed.

The synthesis of amines through N-alkylation is particularly attractive.

The copper-free azide–alkyne click reaction has shown to be a successful alternative to immobilize covalently a fluorescente compound onto poly(-L-lactic) acid (PLLA) surfaces.

Synthesis of mono- and bis-thiosemicarbazones 4a–h and 5a–h of isatin–triazole hybrids 3a and 3b in turn accessed via CuAAC, their DFT studies and potential as phosphoinositide 3-kinase (PI3K) inhibitors has been evaluated in this study.

2-N-Substituted indenones, cyclopentenones or 4-carbonyl oxazoles are prepared from 5-acylated N-fluoroalkyl substituted 1,2,3-triazoles and Lewis acids.

Phenoxathiin-based macrocycles react with RLi reagents to form a number of different products resulting from cleavage of the calixarene backbone or heterocyclic group.

An exceptional achiral and chiral multilayer 3D polymer has been created and controlled by uniform and distinct aromatic chromophore units that are multiply sandwiched by naphthyl berths.

A novel phthalazine derivative exhibited potent cytotoxicity against HCT-116 cells as VEGFR2 inhibitor and apoptosis cell death.

A novel protocol for introducing an acetoxy functional group selectively on the ortho aryl sp² carbon of 2-aryloxyquinoline-3-carbaldehydes in good yields with good functional group tolerance using a palladium catalyst was developed for the first time.

3-Carboxamide indazoles have been developed using the amide coupling process. Density function theory (DFT) computations, and the assessment of binding energy using Auto Dock, illustrate the pharmaceutical effectiveness.

The mechanochemical synthesis of AIE-active amide, as well as the application of the title compound as molecular receptor of monovalent anions and nucleotides, are described.