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Themed collection Journal of Materials Chemistry B Emerging Investigators

27 articles
Profile

Journal of Materials Chemistry B profiles: Contributors to the Emerging Investigators 2017 issue

Journal of Materials Chemistry B profiles: Contributors to the Emerging Investigators issue.

Graphical abstract: Journal of Materials Chemistry B profiles: Contributors to the Emerging Investigators 2017 issue
Highlight

Advancements in infrared imaging platforms: complementary imaging systems and contrast agents

Recent advancements in the design of complementary infrared (IR) fluorescence imaging systems and IR-emitting contrast agents are highlighted. The ability to maximize the full performance of any IR imaging platform relies on the thorough understanding of the requirements of the imaging system and physical characteristics of the complementary contrast agents.

Graphical abstract: Advancements in infrared imaging platforms: complementary imaging systems and contrast agents
Review Article

Interactions of organic nanoparticles with proteins in physiological conditions

The efficacy of nanoparticles in biomedical applications is strongly influenced by their ability to bind proteins onto their surface. The analysis of organic nanoparticles interacting with proteins in physiological conditions may help in the successful design of next generation nanoparticles with improved biodistributions and therapeutic performances.

Graphical abstract: Interactions of organic nanoparticles with proteins in physiological conditions
Review Article

Nanoscale silicon for subcellular biointerfaces

Semiconductor nanomaterials are emerging as a class of materials that can push the fundamental limits of current biomedical devices and possibly revolutionize healthcare.

Graphical abstract: Nanoscale silicon for subcellular biointerfaces
Review Article

Optical nanoprobes for biomedical applications: shining a light on upconverting and near-infrared emitting nanoparticles for imaging, thermal sensing, and photodynamic therapy

Shining a light on spectrally converting lanthanide (Ln3+)-doped nanoparticles: progress, trends, and challenges in Ln3+-nanoprobes for near-infrared bioimaging, nanothermometry, and photodynamic therapy.

Graphical abstract: Optical nanoprobes for biomedical applications: shining a light on upconverting and near-infrared emitting nanoparticles for imaging, thermal sensing, and photodynamic therapy
Review Article

Cultured cell-derived decellularized matrices: a review towards the next decade

Summary of recent progress in cell-derived decellularized matrices preparation and application, with perspectives towards the next decade.

Graphical abstract: Cultured cell-derived decellularized matrices: a review towards the next decade
Review Article

Peptides for tumor-specific drug targeting: state of the art and beyond

This review outlines the most recent advances in peptide-mediated tumor-targeting and gives insight into the direction of the field.

Graphical abstract: Peptides for tumor-specific drug targeting: state of the art and beyond
Review Article

Activatable probes for diagnosis and biomarker detection by MRI

This review describes the strategies employed and the mechanisms behind both 1H and 19F-MRI based activatable probes for diagnosis and biomarker detection.

Graphical abstract: Activatable probes for diagnosis and biomarker detection by MRI
Review Article

Thermo-responsive polymers and their application as smart biomaterials

This review summarises smart thermo-responsive polymeric materials with reversible and ‘on–off’ remotely switchable properties for a wide range of biomedical and biomaterials applications.

Graphical abstract: Thermo-responsive polymers and their application as smart biomaterials
Review Article

Physical principles of graphene cellular interactions: computational and theoretical accounts

Clarifying the physical principles of graphene cellular interactions is critical for the wider application of graphene-based nanomaterials in nanomedicine. This review highlights the advances in computational and theoretical accounts for this emerging field.

Graphical abstract: Physical principles of graphene cellular interactions: computational and theoretical accounts
Open Access Communication

Biocompatible pH-responsive nanoparticles with a core-anchored multilayer shell of triblock copolymers for enhanced cancer therapy

pH-Responsive drug nanocarriers were made via facile self-assembly, showing excellent stability in bio-media (50% PBS/FBS) and enhanced drug efficacy towards cancer cells.

Graphical abstract: Biocompatible pH-responsive nanoparticles with a core-anchored multilayer shell of triblock copolymers for enhanced cancer therapy
Communication

Single-molecule study of the synergistic effects of positive charges and Dopa for wet adhesion

Using AFM based single-molecule force spectroscopy, we studied the synergy between Dopa and lysine for wet adhesion on titania (TiO2) and mica surfaces.

Graphical abstract: Single-molecule study of the synergistic effects of positive charges and Dopa for wet adhesion
Communication

Janus nanoparticles for T cell activation: clustering ligands to enhance stimulation

Janus nanoparticles displaying clustered ligands enhance T cell activation by increasing the local surface density of ligand stimuli.

Graphical abstract: Janus nanoparticles for T cell activation: clustering ligands to enhance stimulation
Communication

Near-infrared absorbing amphiphilic semiconducting polymers for photoacoustic imaging

Near-infrared (NIR) absorbing amphiphilic semiconducting polymers with absorption maximum at 804 nm were designed and synthesized. This polymer can spontaneously self-assemble into homogeneous water-soluble nanoparticles in aqueous solution and efficiently convert photon energy into heat, allowing for photoacoustic imaging of tumor in living mice.

Graphical abstract: Near-infrared absorbing amphiphilic semiconducting polymers for photoacoustic imaging
Paper

The effect of hyperbranched poly(acrylic acid)s on the morphology and size of precipitated nanoscale (fluor)hydroxyapatite

Hydroxyapatite and fluorhydroxyapatite (F)HA nanoparticles were synthesised in the presence of branched poly(acrylic acid)s and compared to those synthesised in the presence of linear PAA.

Graphical abstract: The effect of hyperbranched poly(acrylic acid)s on the morphology and size of precipitated nanoscale (fluor)hydroxyapatite
Paper

ZnO nanoparticles as an antimicrobial tissue adhesive for skin wound closure

A solution of zinc oxide nanoparticles was explored as an antimicrobial tissue adhesive for skin wound closure.

Graphical abstract: ZnO nanoparticles as an antimicrobial tissue adhesive for skin wound closure
Paper

New design of hydrogels with tuned electro-osmosis: a potential model system to understand electro-kinetic transport in biological tissues

A series of charged polymer gels with precisely controlled magnitude and direction of electro-osmotic flow was prepared and opens up the possibility for understanding the contribution of electro-osmosis to transport phenomenon in native biological tissues.

Graphical abstract: New design of hydrogels with tuned electro-osmosis: a potential model system to understand electro-kinetic transport in biological tissues
Paper

Crystallization and sintering of borosilicate bioactive glasses for application in tissue engineering

Typical silicate bioactive glasses are known to crystallize readily during the processing of porous scaffolds. New borosilicate bioactive glass can be sintered without significant sign of crystallization.

Graphical abstract: Crystallization and sintering of borosilicate bioactive glasses for application in tissue engineering
Paper

Electrochemical deposition of dopamine–hyaluronic acid conjugates for anti-biofouling bioelectrodes

Electrochemical deposition of dopamine-hyaluronic acid conjugates onto electrode surfaces can lead to preserved electrochemical activities and anti-biofouling properties of the electrodes.

Graphical abstract: Electrochemical deposition of dopamine–hyaluronic acid conjugates for anti-biofouling bioelectrodes
Paper

Drawing in poly(ε-caprolactone) fibers: tuning mechanics, fiber dimensions and surface-modification density

This work describes the complex interplay between mechanical manipulation of coextruded fibers and the resulting photochemical yield of surface modification.

Graphical abstract: Drawing in poly(ε-caprolactone) fibers: tuning mechanics, fiber dimensions and surface-modification density
Paper

Photomediated oxime ligation as a bioorthogonal tool for spatiotemporally-controlled hydrogel formation and modification

Biocompatible, synthetic hydrogels were formed and modified by photomediated oxime ligation with full spatiotemporal control.

Graphical abstract: Photomediated oxime ligation as a bioorthogonal tool for spatiotemporally-controlled hydrogel formation and modification
Paper

Tunable delayed controlled release profile from layered polymeric microparticles

Solvent evaporation parameters and ethanol content during PLGA/PLLA microparticle (MP) fabrication affect protein distribution and MP structure, thereby altering the protein release profiles.

Graphical abstract: Tunable delayed controlled release profile from layered polymeric microparticles
Paper

A comparison study to investigate the effect of the drug-loading site on its delivery efficacy using double hydrophilic block copolymer-based prodrugs

Two types of thermo-sensitive DHBCs-based micelle prodrugs with drug tethered to the hydrophilic shell or encapsulated with the hydrophobic core was fabricated, and compared further for their drug delivery efficacy.

Graphical abstract: A comparison study to investigate the effect of the drug-loading site on its delivery efficacy using double hydrophilic block copolymer-based prodrugs
Paper

Understanding the functional properties of bio-inorganic nanoflowers as biocatalysts by deciphering the metal-binding sites of enzymes

The biomineralisation of metal phosphates is a promising approach to develop more efficient nanobiocatalysts; elucidating which protein regions most likely participate in the mineral formation will guide the fabrication of more efficient biocatalysts based on metal-phosphate nanoflowers.

Graphical abstract: Understanding the functional properties of bio-inorganic nanoflowers as biocatalysts by deciphering the metal-binding sites of enzymes
Paper

Hydrazone-modulated peptides for efficient gene transfection

The synthetic potential of dynamic bond formation is introduced for the delivery of plasmid DNA by modulated amphiphilic peptides. The synthetic advantage of these dynamic bonds allowed the identification of improved reagents (better efficiency and lower toxicity) for plasmid transfection assays in human HeLa cells.

Graphical abstract: Hydrazone-modulated peptides for efficient gene transfection
Paper

One-pot synthesis of redox-triggered biodegradable hybrid nanocapsules with a disulfide-bridged silsesquioxane framework for promising drug delivery

Redox-triggered biodegradable hybrid nanocapsules with the disulfide-bridged silsesquioxane framework were developed for promising drug delivery.

Graphical abstract: One-pot synthesis of redox-triggered biodegradable hybrid nanocapsules with a disulfide-bridged silsesquioxane framework for promising drug delivery
Paper

GSH-triggered size increase of porphyrin-containing nanosystems for enhanced retention and photodynamic activity

We demonstrate the rational design of a size changeable nanosystem triggered by intracellular GSH for enhanced retention and photodynamic activity.

Graphical abstract: GSH-triggered size increase of porphyrin-containing nanosystems for enhanced retention and photodynamic activity
27 articles

About this collection

Journal of Materials Chemistry B is proud to present this themed issue highlighting 2017’s rising stars of materials chemistry research. This issue gathers the very best work from materials chemists in the early stages of their independent career.

Each contributor was recommended by experts in their fields as carrying out work with the potential to influence future directions in materials chemistry. Congratulations to all of those who feature on their important work so far in the field of materials for biology and medicine.

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