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ZnO nanoparticles as an antimicrobial tissue adhesive for skin wound closure

Abstract

Tissue adhesives have emerged as alternatives to suturing and stapling in the treatment of reconnection of injured tissues. They can be accurately applied to the regions of body that are not easy-to-access in a minimally-invasive way without high level of training. Recently, it has been demonstrated nanoparticles can directly glue hydrogels or tissues without the need of in situ polymerization or crosslinking. For example, silica nanoparticles can serve as connectors between tissues and exhibit adhesion even in the presence of blood. This work reports the adhesive effect of two antimicrobial nanoparticles, i.e. titanium dioxide and zinc oxide nanoparticles, between hydrogels, hydrogel/polymer, and liver tissues. These two nanoparticles exhibit comparable or even better adhesive effects in comparison to silica nanoparticles. In a skin wound mouse model, zinc oxide nanoparticles achieve successful wound closure and aesthetical wound healing, suggesting their ability as an effective antimicrobial tissue adhesive.

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Publication details

The article was received on 10 Mar 2017, accepted on 17 May 2017 and first published on 18 May 2017


Article type: Paper
DOI: 10.1039/C7TB00664K
Citation: J. Mater. Chem. B, 2017, Accepted Manuscript
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    ZnO nanoparticles as an antimicrobial tissue adhesive for skin wound closure

    Y. Gao, Y. Han , M. Cui, H. L. Tey, L. Wang and C. Xu, J. Mater. Chem. B, 2017, Accepted Manuscript , DOI: 10.1039/C7TB00664K

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