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Activatable probes for diagnosis and biomarker detection by MRI

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Abstract

Magnetic resonance imaging (MRI) is a non-invasive imaging technique with widespread use in diagnosis. Frequently, contrast in MRI is enhanced with the aid of a contrast agent, among which smart, responsive, OFF/ON or activatable probes are of particular interest. These kinds of probes elicit a response to selective stimuli, evidencing the presence of enzymes or acidic pH, for instance. In this review, we will focus on smart probes that are detectable by both 1H and 19F MRI, frequently based on nanomaterials. We will discuss the triggering factors and the strategies employed thus far to activate each probe.

Graphical abstract: Activatable probes for diagnosis and biomarker detection by MRI

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Publication details

The article was received on 09 Jan 2017, accepted on 20 Feb 2017 and first published on 20 Feb 2017


Article type: Review Article
DOI: 10.1039/C7TB00093F
Citation: J. Mater. Chem. B, 2017, Advance Article
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    Activatable probes for diagnosis and biomarker detection by MRI

    M. Carril, J. Mater. Chem. B, 2017, Advance Article , DOI: 10.1039/C7TB00093F

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