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Themed collection Mechanobiology

24 articles
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Front cover

Graphical abstract: Front cover
From the themed collection: Mechanobiology
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From the themed collection: Mechanobiology
Editorial

Mechanobiology

Guest editors G. V. Shivashankar, Michael Sheetz and Paul Matsudaira introduce the Mechanobiology themed issue of Integrative Biology.

Graphical abstract: Mechanobiology
From the themed collection: Mechanobiology
Review Article

Multiscale mechanobiology: computational models for integrating molecules to multicellular systems

We review recent computational approaches and supporting experimental work in mechanobiology across multiple scales, from molecules to multicellular systems.

Graphical abstract: Multiscale mechanobiology: computational models for integrating molecules to multicellular systems
From the themed collection: Mechanobiology
Paper

Regulation of epithelial cell organization by tuning cell–substrate adhesion

Combining live cell imaging, particle image velocimetry and numerical simulations, we show the role of extracellular matrix and intercellular adhesion on the expansion of epithelial cells.

Graphical abstract: Regulation of epithelial cell organization by tuning cell–substrate adhesion
From the themed collection: Mechanobiology
Paper

Actin cytoskeleton differentially alters the dynamics of lamin A, HP1α and H2B core histone proteins to remodel chromatin condensation state in living cells

Cellular mechanical signals via the actin cytoskeleton regulate DNA packing by altering the dynamics of nuclear structure proteins.

Graphical abstract: Actin cytoskeleton differentially alters the dynamics of lamin A, HP1α and H2B core histone proteins to remodel chromatin condensation state in living cells
From the themed collection: Mechanobiology
Open Access Paper

Micropatterning of TCR and LFA-1 ligands reveals complementary effects on cytoskeleton mechanics in T cells

Micropatterning of T cell ligands reveals their specific contributions to actin assembly and the generation of cytoskeletal forces in immunesynapse formation.

Graphical abstract: Micropatterning of TCR and LFA-1 ligands reveals complementary effects on cytoskeleton mechanics in T cells
Open Access Paper

Single cell super-resolution imaging of E. coli OmpR during environmental stress

We used super-resolution microscopy to visualize the bacterial transcriptional regulator OmpR, the bacterial membrane and the chromosome.

Graphical abstract: Single cell super-resolution imaging of E. coli OmpR during environmental stress
Paper

Single molecular force across single integrins dictates cell spreading

Molecular forces via single integrins at the cell-substrate interface control the degree of cell spreading.

Graphical abstract: Single molecular force across single integrins dictates cell spreading
From the themed collection: Mechanobiology
Paper

Mechanisms of integrin and filamin binding and their interplay with talin during early focal adhesion formation

Mechanisms of the interplay among filamin, integrin and talin during early focal adhesion formation were explored using molecular dynamics simulations.

Graphical abstract: Mechanisms of integrin and filamin binding and their interplay with talin during early focal adhesion formation
From the themed collection: Mechanobiology
Paper

Modelling wound closure in an epithelial cell sheet using the cellular Potts model

We use a two-dimensional cellular Potts model to represent the behavior of an epithelial cell layer and describe its dynamics in response to a microscopic wound.

Graphical abstract: Modelling wound closure in an epithelial cell sheet using the cellular Potts model
From the themed collection: Mechanobiology
Paper

Modeling the finger instability in an expanding cell monolayer

Curvature-controlled cellular forces at the edge of an expanding monolayer are sufficient for the initiation and growth of finger-like instability.

Graphical abstract: Modeling the finger instability in an expanding cell monolayer
From the themed collection: Mechanobiology
Paper

Ratio of total traction force to projected cell area is preserved in differentiating adipocytes

During obesity development, preadipocytes proliferate and differentiate into new mature adipocytes, to increase the storage capacity of triglycerides.

Graphical abstract: Ratio of total traction force to projected cell area is preserved in differentiating adipocytes
From the themed collection: Mechanobiology
Paper

Deterministic control of mean alignment and elongation of neuron-like cells by grating geometry: a computational approach

Combinatorial simulations are able to relate alignment and elongation of neuron-like cells on gratings.

Graphical abstract: Deterministic control of mean alignment and elongation of neuron-like cells by grating geometry: a computational approach
From the themed collection: Mechanobiology
Paper

Traction stress analysis and modeling reveal that amoeboid migration in confined spaces is accompanied by expansive forces and requires the structural integrity of the membrane–cortex interactions

Neutrophil-like cells, confined between two non-fibronectin-coated gels, form blebs and generate expansive forces against opposing surfaces during amoeboid cell “chimneying”.

Graphical abstract: Traction stress analysis and modeling reveal that amoeboid migration in confined spaces is accompanied by expansive forces and requires the structural integrity of the membrane–cortex interactions
From the themed collection: Mechanobiology
Paper

Quantifying cell-induced matrix deformation in three dimensions based on imaging matrix fibers

An experimental technique that images fibers of an extracellular matrix to quantify cell-induced deformations and microstructural changes in three dimensions.

Graphical abstract: Quantifying cell-induced matrix deformation in three dimensions based on imaging matrix fibers
From the themed collection: Mechanobiology
Open Access Paper

Non-monotonic cellular responses to heterogeneity in talin protein expression-level

Correlative imaging in single-cells of both live migration and post-fixation talin-labeling revealed non-monotonic correspondences between cellular properties and talin expression-levels.

Graphical abstract: Non-monotonic cellular responses to heterogeneity in talin protein expression-level
Paper

Human breast cancer invasion and aggression correlates with ECM stiffening and immune cell infiltration

Human tumors are stiff and data suggest that the extracellular matrix stiffening is consistent with experimental mammary tumor models in which stiffness drives tumor invasion and metastasis.

Graphical abstract: Human breast cancer invasion and aggression correlates with ECM stiffening and immune cell infiltration
From the themed collection: Mechanobiology
Paper

Oxygen governs gonococcal microcolony stability by enhancing the interaction force between type IV pili

Bacterial cell clusters disassemble after having depleted oxygen because the interaction force between their surface appendages is reduced.

Graphical abstract: Oxygen governs gonococcal microcolony stability by enhancing the interaction force between type IV pili
From the themed collection: Mechanobiology
Open Access Paper

Thermodynamics of force-dependent folding and unfolding of small protein and nucleic acid structures

A theoretical framework for understanding equilibrium mechanical stretching of single proteins.

Graphical abstract: Thermodynamics of force-dependent folding and unfolding of small protein and nucleic acid structures
Paper

Microtubule appendages mediating T-cell motility and polarity

Motility and polarity of T cells are mediated in large measure by differential adhesion through the long, flexible microtubule-based appendages.

Graphical abstract: Microtubule appendages mediating T-cell motility and polarity
From the themed collection: Mechanobiology
Paper

Substrate elasticity modulates the responsiveness of mesenchymal stem cells to commitment cues

Fate choices of stem cells are regulated in response to a complex array of biochemical and physical signals from their microenvironmental niche.

Graphical abstract: Substrate elasticity modulates the responsiveness of mesenchymal stem cells to commitment cues
From the themed collection: Mechanobiology
Technical Innovation

High-throughput screening for modulators of cellular contractile force

Using cellular contractile force as the target, we report a new high-throughput screening technology.

Graphical abstract: High-throughput screening for modulators of cellular contractile force
From the themed collection: Mechanobiology
Frontier

The mechanotransduction machinery at work at adherens junctions

α-Catenin, the core mechanosensor of adherens junctions, allows cells to sense, transduce mechanical constrain in biochemical signals by force-dependent conformational changes regulating protein interactions.

Graphical abstract: The mechanotransduction machinery at work at adherens junctions
From the themed collection: Mechanobiology
24 articles

About this collection

This themed issue on mechanobiology, guest edited by G. V. Shivashankar, M .P. Sheetz and P. Matsudaira, features original research and topical mini review articles on all areas of mechanobiology from molecular to organ scale, experimental, theoretical and computational analysis. Topics covered include: molecules and motors, mechanics of molecular motors in living cells, cell models of mechanobiology, mechanotransduction & genome regulation, mechanics of cellular differentiation/reprogramming, collective cell migration & tissue mechanics, mechanobiology of pathogenesis and cancer, bacterial mechanics and multiscale modeling in mechanobiology. We hope you enjoy this collection.

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