Issue 17, 2016
From the journal:

Organic & Biomolecular Chemistry

Spatial conservation studies of nucleobases in 10–23 DNAzyme by 2′-positioned isonucleotides and enantiomers for increased activity†

Xiantao Yang,‡a   Zhangping Xiao,‡a   Junfei Zhu,b   Zhiwen Li,b   Junlin He,*c   Lihe Zhanga  and  Zhenjun Yang*a  

* Corresponding authors

a State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing, China
E-mail: yangzj@bjmu.edu.cn

b College of Life Sciences, Guizhou University, Guiyang 550025, China

c Beijing Institute of Pharmacology and Toxicology, Taiping Road 27, Beijing 100850, China
E-mail: hejunlin@bmi.ac.cn

Abstract

2′-Positioned isonucleotides and enantiomers were used to evaluate the conservation of the spatial location of five adenines and two thymines in the catalytic core of 10–23 DNAzyme. The positive effect of isonucleotides at A15 and T8 along with inherent enzymatic resistance could be a tangible solution for the practical applications of 10–23 DNAzyme.

Graphical abstract: Spatial conservation studies of nucleobases in 10–23 DNAzyme by 2′-positioned isonucleotides and enantiomers for increased activity

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Article information

DOI
https://doi.org/10.1039/C6OB00390G
Article type
Paper
Submitted
19 Feb 2016
Accepted
09 Mar 2016
First published
09 Mar 2016

Org. Biomol. Chem., 2016,14, 4032-4038

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Spatial conservation studies of nucleobases in 10–23 DNAzyme by 2′-positioned isonucleotides and enantiomers for increased activity

X. Yang, Z. Xiao, J. Zhu, Z. Li, J. He, L. Zhang and Z. Yang, Org. Biomol. Chem., 2016, 14, 4032 DOI: 10.1039/C6OB00390G

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