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Gold Nanocages and Nanoshells Fabrication Using Lanreotide Acetate and Comparison Study of Their Photothermal Antitumor Therapy

Abstract

Gold nanostructures, particularly gold nanocages or nanoshells (AuNCs or AuNSs), exhibit remarkable optical properties due to their excellent surface plasmon resonance, allowing their potential use in biomedical fields. We report here the controlled synthesis of AuNCs and AuNSs simply using lanreotide acetate (Lan) as a biotemplate. The gold nanomaterials were obtained by co-incubation between HAuCl4 solution and Lan peptide and controlling reduction reaction process. AuNCs and AuNSs prepared in this method were appropriately 120 nm and 150 nm in diameter, respectively, which have desired passive targeting to tumor. Breathtakingly, both AuNCs and AuNSs showed superior photothermal inhibitory effects for cancer cells with only 0.8 W/cm2 of laser power in the in vivo and vitro experiments, meanwhile, the AuNCs showed better antitumor activity and photothermal conversion efficiency than AuNSs. In this study, two kinds of gold nanostructures were fabricated by the same template molecule, and AuNCs showed higher photothermal conversion efficiency due to their anisotropic structure.

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Publication details

The article was received on 26 Apr 2017, accepted on 15 Jun 2017 and first published on 15 Jun 2017


Article type: Paper
DOI: 10.1039/C7TB01146F
Citation: J. Mater. Chem. B, 2017, Accepted Manuscript
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    Gold Nanocages and Nanoshells Fabrication Using Lanreotide Acetate and Comparison Study of Their Photothermal Antitumor Therapy

    W. Xue, L. Luo, Y. Li, T. Yin, K. Bian, R. Zhu and D. Gao, J. Mater. Chem. B, 2017, Accepted Manuscript , DOI: 10.1039/C7TB01146F

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