Issue 28, 2017

Toxicity and oxidative stress responses induced by nano- and micro-CoCrMo particles

Abstract

Metal implants are used routinely during total hip and knee replacements and are typically composed of cobalt chromium molybdenum (CoCrMo) alloys. CoCrMo “wear particles”, in the nano- and micro-size ranges, are generated in situ. Meanwhile, occupational exposure to CoCrMo particles may be associated with the development of industrial dental worker's pneumoconiosis. In this study, we report that both nano- and micro-CoCrMo induced a time and dose-dependent toxicity in various cell types (i.e. lung epithelial cells, osteoblasts, and macrophages), and the effects of particle size on cell viability and oxidative responses were interesting and cell specific. Our findings highlight the potential roles that nano- and micro-CoCrMo, whether exposure is due to inhalation or implant wear, and the associated oxidative stress may play in the increasingly reported implant loosening, osteolysis, and systemic complications in orthopaedic patients, and may explain the risk of lung diseases in dental workers.

Graphical abstract: Toxicity and oxidative stress responses induced by nano- and micro-CoCrMo particles

Supplementary files

Article information

Article type
Paper
Submitted
18 May 2017
Accepted
13 Jun 2017
First published
15 Jun 2017

J. Mater. Chem. B, 2017,5, 5648-5657

Toxicity and oxidative stress responses induced by nano- and micro-CoCrMo particles

A. L. Armstead, T. A. Simoes, X. Wang, R. Brydson, A. Brown, B. Jiang, Y. Rojanasakul and B. Li, J. Mater. Chem. B, 2017, 5, 5648 DOI: 10.1039/C7TB01372H

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements