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Highly regio- and stereoselective trans-iodofluorination of ynamides enabling the synthesis of (E)-α-fluoro-β-iodoenamides

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Abstract

A highly regio- and stereoselective trans-iodofluorination reaction of ynamides with NIS and Et3N·3HF has been achieved, affording (E)-α-fluoro-β-iodoenamides in moderate to good yields. The reaction proceeds under mild reaction conditions and exhibits good functional group compatibility.

Graphical abstract: Highly regio- and stereoselective trans-iodofluorination of ynamides enabling the synthesis of (E)-α-fluoro-β-iodoenamides

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Publication details

The article was received on 16 Jun 2017, accepted on 09 Aug 2017 and first published on 09 Aug 2017


Article type: Paper
DOI: 10.1039/C7OB01470H
Citation: Org. Biomol. Chem., 2017, Advance Article
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    Highly regio- and stereoselective trans-iodofluorination of ynamides enabling the synthesis of (E)-α-fluoro-β-iodoenamides

    Y. Xi, G. Zhu, L. Tang, S. Ma, D. Zhang, R. Zhang, G. He and H. Zhu, Org. Biomol. Chem., 2017, Advance Article , DOI: 10.1039/C7OB01470H

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