Issue 34, 2017
From the journal:

Organic & Biomolecular Chemistry

Palladium-catalyzed allylic amination: a powerful tool for the enantioselective synthesis of acyclic nucleoside phosphonates†

Mariam Azzouz,a   Sébastien Soriano,a   Margarita Escudero-Casao, ORCID logo a   M. Isabel Matheu, ORCID logo a   Sergio Castillón ORCID logo *a  and  Yolanda Díaz ORCID logo *a  

* Corresponding authors

a Departament de Química Analítica I Química Orgànica, Facultat de Química, Universitat Rovira i Virgili, C/Marcel·lí Domingo 1, 43007 Tarragona, Spain
E-mail: yolanda.diaz@urv.cat, sergio.castillon@urv.cat

Abstract

Acyclic nucleoside phosphonates have been prepared in a straightforward manner and in high yields by an enantioselective palladium-catalyzed allylic substitution involving nucleic bases as nucleophiles followed by cross-metathesis reaction with diethyl allylphosphonate.

Graphical abstract: Palladium-catalyzed allylic amination: a powerful tool for the enantioselective synthesis of acyclic nucleoside phosphonates

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Article information

DOI
https://doi.org/10.1039/C7OB01478C
Article type
Paper
Submitted
19 Jun 2017
Accepted
07 Aug 2017
First published
10 Aug 2017
This article is Open Access
Creative Commons BY-NC license

Org. Biomol. Chem., 2017,15, 7227-7234

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Palladium-catalyzed allylic amination: a powerful tool for the enantioselective synthesis of acyclic nucleoside phosphonates

M. Azzouz, S. Soriano, M. Escudero-Casao, M. I. Matheu, S. Castillón and Y. Díaz, Org. Biomol. Chem., 2017, 15, 7227 DOI: 10.1039/C7OB01478C

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