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Issue 6, 2012
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The early stages of taxol biosynthesis: An interim report on the synthesis and identification of early pathway metabolites

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Abstract

Covering: 1966 to 2012

The biosynthesis of the anti-cancer drug taxol (paclitaxel) has required the collaborative efforts of several research groups to tackle the synthesis and labeling of putative biosynthetic intermediates, in concert with the identification, cloning and functional expression of the biosynthetic genes responsible for the construction of this complex natural product. Based on a combination of precursor labeling and incorporation experiments, and metabolite isolation from Taxus spp., a picture of the complex matrix of pathway oxygenation reactions following formation of the first committed intermediate, taxa-4(5),11(12)-diene, is beginning to emerge. An overview of the current state of knowledge on the early-stages of taxol biosynthesis is presented.

Graphical abstract: The early stages of taxol biosynthesis: An interim report on the synthesis and identification of early pathway metabolites

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Publication details

The article was received on 14 Feb 2012 and first published on 01 May 2012


Article type: Review Article
DOI: 10.1039/C2NP20021J
Citation: Nat. Prod. Rep., 2012,29, 683-696
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    The early stages of taxol biosynthesis: An interim report on the synthesis and identification of early pathway metabolites

    J. Guerra-Bubb, R. Croteau and R. M. Williams, Nat. Prod. Rep., 2012, 29, 683
    DOI: 10.1039/C2NP20021J

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