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Issue 6, 2012
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Glycosynthases as tools for the production of glycan analogs of natural products

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Abstract

Covering: up to March 2012

Oligo-, polysaccharides, and glycoconjugates are a relevant part of the bioactive components of the natural products exploited in therapeutics, diagnostics, food additives, and biomaterials. Glycans are directly involved in important biological processes, such as immunostimulation, anti-inflammatory, antioxidant, and chemoprotectant actions and/or are crucial for their activity, by modulating target recognition, stability, and pharmacokinetics. On the other hand, carbohydrate extracts used for functional studies are rather heterogeneous and lack structural information because of their intrinsic complexity hampering purification and characterization. Therefore, methods for glycoside synthesis and modification are urgently needed. Recently, glycosynthases, engineered glycoside hydrolases with no hydrolytic activity that synthesize glycans in quantitative yields, were introduced. Here we will illustrate how the glycosynthases described so far might be exploited for the production of glycan analogs of natural products and their enormous potential in this field.

Graphical abstract: Glycosynthases as tools for the production of glycan analogs of natural products

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Publication details

The article was received on 08 Mar 2012 and first published on 16 Apr 2012


Article type: Review Article
DOI: 10.1039/C2NP20032E
Citation: Nat. Prod. Rep., 2012,29, 697-709
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    Glycosynthases as tools for the production of glycan analogs of natural products

    B. Cobucci-Ponzano and M. Moracci, Nat. Prod. Rep., 2012, 29, 697
    DOI: 10.1039/C2NP20032E

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