Jump to main content
Jump to site search

Issue 11, 2012
Previous Article Next Article

Cargo-towing synthetic nanomachines: Towards active transport in microchip devices

Author affiliations

Abstract

This review article discusses the use of synthetic catalytic nano motors for cargo manipulations and for developing miniaturized lab-on-chip systems based on autonomous transport. The ability of using chemically-powered artificial nanomotors to capture, transport and release therapeutic payloads or nanostructured biomaterials represents one of the next major prospects for nanomotor development. The increased cargo-towing force of such self-propelled nanomotors, along with their precise motion control within microchannel networks, versatility and facile functionalization, pave the way to new integrated functional lab-on-a-chip powered by active transport and perform a series of tasks. Such use of cargo-towing artificial nanomotors has been inspired by on-chip kinesin molecular shuttles. Functionalized nano/microscale motors can thus be used to pick a selected nano/microscale chemical or biological payload target at the right place, transport and deliver them to a target location in a timely manner. Key challenges for using synthetic nanomachines for driving transport processes along microchannel networks are discussed, including loading and unloading of cargo and precise motion control, along with recent examples of related cargo manipulation processes and guided transport in lab-on-a-chip formats. The exciting research area of cargo-carrying catalytic man-made nanomachines is expected to grow rapidly, to lead to new lab-on-a-chip formats and to provide a wide range of future microchip opportunities.

Graphical abstract: Cargo-towing synthetic nanomachines: Towards active transport in microchip devices

Back to tab navigation

Publication details

The article was received on 02 Jan 2012, accepted on 16 Feb 2012 and first published on 17 Feb 2012


Article type: Critical Review
DOI: 10.1039/C2LC00003B
Citation: Lab Chip, 2012,12, 1944-1950
  •   Request permissions

    Cargo-towing synthetic nanomachines: Towards active transport in microchip devices

    J. Wang, Lab Chip, 2012, 12, 1944
    DOI: 10.1039/C2LC00003B

Search articles by author

Spotlight

Advertisements