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Issue 11, 2012
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Recent advances in transition metal-catalyzed enantioselective hydrogenation of unprotected enamines

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Abstract

Transition metal-catalyzed enantioselective hydrogenation of enamines is undoubtedly a useful and environment-friendly method for the preparation of optically pure chiral amines and amine derivatives. Over the last few decades, the use of transition metal catalysts containing chiral phosphorus or phosphine–oxazoline ligands attracted much attention for the hydrogenation of unprotected enamines. A number of efficient chiral catalysts have been developed, and some of them have shown high potential for the application in the synthesis of optical chiral amines in both laboratory and industry. This tutorial review focuses on the contributions concerning the transition metal-catalyzed enantioselective hydrogenation of unprotected enamines for the synthesis of chiral amines and amine derivatives.

Graphical abstract: Recent advances in transition metal-catalyzed enantioselective hydrogenation of unprotected enamines

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Publication details

The article was received on 10 Jan 2012 and first published on 16 Apr 2012


Article type: Tutorial Review
DOI: 10.1039/C2CS35007F
Citation: Chem. Soc. Rev., 2012,41, 4126-4139
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    Recent advances in transition metal-catalyzed enantioselective hydrogenation of unprotected enamines

    J. Xie, S. Zhu and Q. Zhou, Chem. Soc. Rev., 2012, 41, 4126
    DOI: 10.1039/C2CS35007F

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