Jump to main content
Jump to site search
PLANNED MAINTENANCE Close the message box

Scheduled maintenance upgrade on Thursday 4th of May 2017 from 8.00am to 9.00am (BST).

During this time our websites will be offline temporarily. If you have any questions please use the feedback button on this page. We apologise for any inconvenience this might cause and thank you for your patience.


Issue 11, 2012
Previous Article Next Article

Recent advances in transition metal-catalyzed enantioselective hydrogenation of unprotected enamines

Author affiliations

Abstract

Transition metal-catalyzed enantioselective hydrogenation of enamines is undoubtedly a useful and environment-friendly method for the preparation of optically pure chiral amines and amine derivatives. Over the last few decades, the use of transition metal catalysts containing chiral phosphorus or phosphine–oxazoline ligands attracted much attention for the hydrogenation of unprotected enamines. A number of efficient chiral catalysts have been developed, and some of them have shown high potential for the application in the synthesis of optical chiral amines in both laboratory and industry. This tutorial review focuses on the contributions concerning the transition metal-catalyzed enantioselective hydrogenation of unprotected enamines for the synthesis of chiral amines and amine derivatives.

Graphical abstract: Recent advances in transition metal-catalyzed enantioselective hydrogenation of unprotected enamines

Back to tab navigation
Please wait while Download options loads

Publication details

The article was received on 10 Jan 2012 and first published on 16 Apr 2012


Article type: Tutorial Review
DOI: 10.1039/C2CS35007F
Citation: Chem. Soc. Rev., 2012,41, 4126-4139
  •   Request permissions

    Recent advances in transition metal-catalyzed enantioselective hydrogenation of unprotected enamines

    J. Xie, S. Zhu and Q. Zhou, Chem. Soc. Rev., 2012, 41, 4126
    DOI: 10.1039/C2CS35007F

Search articles by author