Activation of the hypervalent fluoroiodane reagent by hydrogen bonding to hexafluoroisopropanol†
Alison M.
Stuart 
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Abstract
Hexafluoroisopropan-2-ol (HFIP) is an excellent solvent for promoting fluorinations with the hypervalent fluoroiodane reagent 1 and crucially, it removes the need for transition metals or TREAT-HF activators. The fluoroiodane reagent 1 was used in HFIP to monofluorinate 1,3-ketoesters and to fluorocyclise unsaturated carboxylic acids in excellent yields under mild reaction conditions.
- This article is part of the themed collections: Synthetic methodology in OBC and Fluorine Chemistry
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