Issue 40, 2024

Gold-catalyzed benzannulations of 2-alkenylindoles with alkynes: a protecting-group-free regioselective approach to carbazoles

Abstract

A gold(I)-catalyzed protecting-group-free benzannulation approach to functionalized NH-carbazoles was accomplished via the hydroarylation of alkynes with 2-alkenylindoles. A broad spectrum of terminal and internal alkynes and 2-alkenylindoles successfully participated in this annulation reaction. The protocol efficiently enabled the formation of substituted NH-carbazoles with moderate to specific regioselectivities. The synthetic utility of this protocol was demonstrated by a variety of post-functionalizations.

Graphical abstract: Gold-catalyzed benzannulations of 2-alkenylindoles with alkynes: a protecting-group-free regioselective approach to carbazoles

Supplementary files

Article information

Article type
Communication
Submitted
12 1月 2024
Accepted
22 4月 2024
First published
22 4月 2024

Chem. Commun., 2024,60, 5326-5329

Gold-catalyzed benzannulations of 2-alkenylindoles with alkynes: a protecting-group-free regioselective approach to carbazoles

P. M. Amin, W. Wang, C. Wang, J. Zhou and Y. Wang, Chem. Commun., 2024, 60, 5326 DOI: 10.1039/D4CC00176A

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