Issue 14, 2014

Targeting a c-MYC G-quadruplex DNA with a fragment library

Abstract

We report here on the screening of a fragment library against a G-quadruplex element in the human c-MYC promoter. The ten fragment hits had significant concordance between a biophysical assay, in silico modelling and c-MYC expression inhibition, highlighting the feasibility of applying a fragment-based approach to the targeting of a quadruplex nucleic acid.

Graphical abstract: Targeting a c-MYC G-quadruplex DNA with a fragment library

Supplementary files

Article information

Article type
Communication
Submitted
01 11月 2013
Accepted
25 11月 2013
First published
26 11月 2013

Chem. Commun., 2014,50, 1704-1707

Targeting a c-MYC G-quadruplex DNA with a fragment library

H. R. Nasiri, N. M. Bell, K. I. E. McLuckie, J. Husby, C. Abell, S. Neidle and S. Balasubramanian, Chem. Commun., 2014, 50, 1704 DOI: 10.1039/C3CC48390H

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements