Issue 8, 2015

Myoglobin-catalyzed intermolecular carbene N–H insertion with arylamine substrates

Abstract

Engineered variants of the heme-containing protein myoglobin can efficiently catalyze the insertion of α-diazo esters into the N–H bond of arylamines, featuring a combination of high chemoselectivity, elevated turnover numbers, and broad substrate scope.

Graphical abstract: Myoglobin-catalyzed intermolecular carbene N–H insertion with arylamine substrates

Associated articles

Supplementary files

Article information

Article type
Communication
Submitted
03 ⵏⵓⵡ 2014
Accepted
02 ⴷⵓⵊ 2014
First published
03 ⴷⵓⵊ 2014

Chem. Commun., 2015,51, 1532-1534

Author version available

Myoglobin-catalyzed intermolecular carbene N–H insertion with arylamine substrates

G. Sreenilayam and R. Fasan, Chem. Commun., 2015, 51, 1532 DOI: 10.1039/C4CC08753D

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