[Ru(η6-p-cymene)Cl2(pta)] (pta = 1,3,5-triaza-7-phosphatricyclo- [3.3.1.1]decane): a water soluble compound that exhibits pH dependent DNA binding providing selectivity for diseased cells

Claire S. Allardyce; Paul J. Dyson; David J. Ellis; Sarah L. Heath

doi:10.1039/B104021A

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[Ru(η⁶-p-cymene)Cl₂(pta)] (pta = 1,3,5-triaza-7-phosphatricyclo- [3.3.1.1]decane): a water soluble compound that exhibits pH dependent DNA binding providing selectivity for diseased cells

Claire S. Allardyce,^a Paul J. Dyson,*^a David J. Ellis^a and Sarah L. Heath^a

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* Corresponding authors

^a Department of Chemistry, The University of York, Heslington, York, UK
E-mail: pjd14@york.ac.uk

Abstract

The water soluble complex [Ru(η⁶-p-cymene)Cl₂(pta)] (pta = 1,3,5-triaza-7-phosphatricyclo[3.3.1.1]decane), exhibits pH dependent DNA damage; the pH at which damage is greatest correlates well to the pH environment of cancer cells.

This article is part of the themed collections: ChemComm contributions to the United Nations Sustainable Development Goals and ChemComm 60th Anniversary Historic Papers from the United Kingdom

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Crystal structure data TXT (38K)

Article information

DOI: https://doi.org/10.1039/B104021A
Article type: Communication
Submitted: 04 ⵎⴰⵢ 2001
Accepted: 20 ⵢⵓⵏ 2001
First published: 11 ⵢⵓⵍ 2001

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Chem. Commun., 2001, 1396-1397

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[Ru(η⁶-p-cymene)Cl₂(pta)] (pta = 1,3,5-triaza-7-phosphatricyclo- [3.3.1.1]decane): a water soluble compound that exhibits pH dependent DNA binding providing selectivity for diseased cells

C. S. Allardyce, P. J. Dyson, D. J. Ellis and S. L. Heath, Chem. Commun., 2001, 1396 DOI: 10.1039/B104021A

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