Issue 71, 2018

Stereoselective aldol reactions using pseudo C2 symmetric 1-benzyl-4-(trifluoromethyl)piperidine-2,6-dione

Abstract

Crossed aldol reactions of the CF3-containing pseudo C2 symmetric cyclic imide 3 were carried out by way of the corresponding boron bisenolate to stereoselectively furnish the desired products 4 and this procedure allowed the preferential construction of the diastereomers of the compounds previously obtained from the acyclic counterpart 1.

Graphical abstract: Stereoselective aldol reactions using pseudo C2 symmetric 1-benzyl-4-(trifluoromethyl)piperidine-2,6-dione

Supplementary files

Article information

Article type
Communication
Submitted
06 ⵢⵓⵍ 2018
Accepted
06 ⵖⵓⵛ 2018
First published
06 ⵖⵓⵛ 2018

Chem. Commun., 2018,54, 9913-9916

Stereoselective aldol reactions using pseudo C2 symmetric 1-benzyl-4-(trifluoromethyl)piperidine-2,6-dione

Y. Inoue, T. Hatayama, T. Kawasaki-Takasuka, T. Agou, T. Kubota and T. Yamazaki, Chem. Commun., 2018, 54, 9913 DOI: 10.1039/C8CC05458D

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