We demonstrate the first application of mechanochemistry to conduct the synthesis of sulfonyl-(thio)ureas, including known anti-diabetic drugs tolbutamide, chlorpropamide and glibenclamide, in good to excellent isolated yields by either stoichiometric base-assisted or copper-catalysed coupling of sulfonamides and iso(thio)cyanates.
D. Tan, V. Štrukil, C. Mottillo and T. Friščić, Chem. Commun., 2014, 50, 5248 DOI: 10.1039/C3CC47905F
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