Themed collection Injectable Hydrogels

Julieta Paez and Khoon Lim introduce the Journal of Materials Chemistry B and Biomaterials Science themed collection on injectable hydrogels.

Injectable hydrogels emerging as a significant breakthrough in the myriad of biomedical applications and paving a path towards clinical advancements.

This review summarizes composition and preparation methodologies of injectable hydrogels and highlights the delivery mechanisms of drugs for tumor therapy, along with discussion on the optimal therapeutic efficiency of drugs and provides perspective on challenges and solutions in applications.

Fabricating injectable hydrogels via tunable molecular interactions for bio-applications.

This review makes a comprehensive summary on the cross-linking mechanism, optimization of mechanical properties, drug loading and release modalities, and recent biological applications of CD-based supramolecular hydrogels.

The synergistic integration of natural and synthetic materials, capitalizing on their respective advantages and mitigating their weaknesses, represents a rational strategy for the development of an ideal injectable smart stimuli-responsive hydrogel.

Injectable hydrogels and cell-based myocardial infarction (MI) therapy mutually enhance each other. This review focuses on recent studies using hydrogel to deliver cell or cell-derived preparations for MI treatment.

Multifunctional hydrogels play a pivotal role against infections, inflammation, and oxidative stress, especially for endodontics and periodontics treatment.

Injectable hydrogels intended for cancer combinatorial-photothermal therapy bring forward the possibility of attaining multifunctional systems for an improved and selective treatment for this disease.

Human-derived methacryloyl platelet lysates (PLMA) have been employed for constructing full human-based 3D cell culture matrices and demonstrated potential for xeno-free applications.

In this work, a hydrogel dressing for controlled release of hydrogen sulfide is developed for the repair of scalded wounds. It exhibits a responsive release of H₂S based on ROS concentration, allowing precise modulation of the wound microenvironment.

This study introduces gelatinized dECM, a tissue-specific rheological modifier, enabling high-resolution printing of flexible tissue constructs with enhanced resilience.

In this study, we combined the β-sheet mediated self-stiffening ability of silk with growth factor presenting ability of sulphated carboxymethyl cellulose in an injectable interpenetrating network hydrogel for repair of articular cartilage defects.

Injectable thermosensitive hydrogels based on hyaluronic acid (HA) grafted with lower critical solution temperature (LCST) polyoxazoline (copolymers of poly(isopropyl-co-butyl oxazoline)) or P(iPrOx-co-BuOx) have been elaborated with tunable solution/gel temperature transitions and gel state elastic modulus.

A regenerated silk fibroin hydrogel is facilely printed by a screen to obtain injectable microparticles. The microparticles possess desirable biocompatibility and lasting filling effects and have great potential for facial rejuvenation.

A novel injectable self-healing adhesive hydrogel with specific bacteria capture capability and inherent contact antimicrobial activity for mild photothermal therapy and NO controlled release to synergically eliminate biofilm infections and promote wound healing.

Unlocking the power of synergy: PAS-loaded thermosensitive hydrogel for enhanced skin wound infection management.

A CuS–curcumin hybrid hydrogel with good biocompatibility, NIR-enhanced antibacterial, antioxidant, anti-inflammatory, and angiogenesis properties has been developed for infected wound healing.

The combination of discogenic factors with biomimetic collagen/hyaluronan hydrogels is promising for disc regeneration; a high content of hyaluronan is responsible for the BM-MSC differentiation into NP like cells.

The mechanism and characteristics of injectable asymmetric hydrogel for large-scale skin trauma repair.

Studies in vivo demonstrated that the MCOAC hydrogel exhibited superior performance in promoting cartilage tissue growth in articular cartilage defects. The MCOAC hydrogel is a promising cartilage repair hydrogel with potential for clinical use.

Here, an oxygen self-supplying nanozyme-based injectable hydrogel is constructed. Both in vitro and in vivo results indicate that the MTC gel has excellent antibiofilm ability with no side effects on normal tissues.

Konjac glucomannan was oxidized using NaIO₄ and subsequently reacted with ε-polylysine to form a drug-loaded adhesive hydrogel. The hydrogel was then utilized as a hemostatic dressing.

Schematic illustration of osteoimmunity-regulating injectable SA/MMT/HM hydrogel composites for enhanced bone regeneration via M2 macrophage polarization.

An important challenge in tissue engineering is the regeneration of functional articular cartilage (AC).

Biomechanical characterization of a fibrinogen–blood hydrogel for human dental pulp regeneration.

A novel sono-activatable prodrug hydrogel was developed to achieve deep-tissue sono-immunotherapy of orthotopic glioblastoma.

An injectable fluorescent hydrogel was successfully prepared by fluorescent polyurethane emulsion cross-linked with oxidized dextran for non-invasive monitoring.

Protein-based biomaterials, particularly amyloids, have sparked considerable scientific interest in recent years due to their exceptional mechanical strength, excellent biocompatibility and bioactivity.

This study introduces a novel antibacterial multifunctional hydrogel with synergistic chemodynamic and photothermal features for wound healing applications.

This study presents a novel photothermally active hydrogel that contains platelet-rich plasma for infected wound healing. The hydrogel showed antibacterial, antioxidant, and hemostatic properties, as well as sustained growth factor release.

A unique self-drug-delivery approach providing chemoimmunotherapy in combating deadly melanoma has been developed from a Zn(II)-coordination complex-based hydrogel; M1-macrophages for activating T cells triggering apoptosis was confirmed in in vivo.