Pd/Cu-catalyzed dual C–H bond carbonylation towards the synthesis of fluorazones

Abstract

Pd/Cu catalyzed oxidative dual C–H bond activation/carbonylation still remains a great challenge due to the generation of by-products via C–C bond formation. Herein we developed a straightforward Pd/Cu-catalyzed oxidative dual C–H bond carbonylation process to access biologically and pharmaceutically important fluorazones from easily available N-aryl pyrroles and CO. A wide range of functional groups were well tolerated in this transformation, and O₂ could be utilized as the only terminal oxidant to promote the oxidative carbonylation process.