Issue 4, 2015

Studies on polymorph conversion in a new cyclodextrin inclusion compound

Abstract

A novel β-cyclodextrin (βCD) inclusion compound was prepared using 4-phenylpyridine-N-oxide (PPNO) as the organic guest. The inclusion compound, βCD·PPNO, was characterised both in solution and in the solid state using numerous techniques. 1H NMR in aqueous solution allowed the determination of a 1 : 1 stoichiometry and an association constant of 164 ± 21 M−1. Powder and single-crystal X-ray diffraction studies showed the formation of two distinct crystal phases, appearing at different timings. Over time, one of the crystal phases converts spontaneously into the other. This work is the first to monitor the conversion of different polymorphs of cyclodextrin inclusion compounds in real time.

Graphical abstract: Studies on polymorph conversion in a new cyclodextrin inclusion compound

Supplementary files

Article information

Article type
Paper
Submitted
09 Nhl 2014
Accepted
21 Huk 2014
First published
25 Huk 2014

CrystEngComm, 2015,17, 937-946

Studies on polymorph conversion in a new cyclodextrin inclusion compound

J. A. Fernandes, A. I. Ramos, P. Ribeiro-Claro, F. A. Almeida Paz and S. S. Braga, CrystEngComm, 2015, 17, 937 DOI: 10.1039/C4CE02041C

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