Issue 95, 2023
From the journal:

Chemical Communications

Hyperbranched polyphthalocyanine micelles with dual PTT/PDT functions for bacteria eradication under an NIR window†

Ying Du,‡a   Guangyu Chu,‡b   Rui Yu,c   Rui Cui,a   Yuling Wang,a   Yiyong Mai, ORCID logo a   Ming Guan,*b   Fugui Xu*a  and  Yongfeng Zhou ORCID logo *a  

* Corresponding authors

a School of Chemistry and Chemical Engineering, Frontiers Science Center for Transformative Molecules, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai 200240, China
E-mail: yfzhou@sjtu.edu.cn, xufg1227@sjtu.edu.cn

b Department of Orthopedic Surgery, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, China
E-mail: guanm@zju.edu.cn

c Department of Human Biology, University of Toronto Scarborough Campus Toronto, Ontario, Canada

Abstract

A Zinc phthalocyanine-based (ZnPc–PA) polymeric micelle around 70 nm and with dual-modal PTT/PDT functions for non-antibiotic bacteria eradication was developed. It showed an excellent bacterial killing efficiency of 95.2% and 96.7% in vitro against Methicillin-resistant Staphylococcus aureus (MRSA) and its biofilm, respectively. Furthermore, the in vivo experiments proved its great potential for implant-associated infection (IAI).

Graphical abstract: Hyperbranched polyphthalocyanine micelles with dual PTT/PDT functions for bacteria eradication under an NIR window

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Article information

DOI
https://doi.org/10.1039/D3CC04082H
Article type
Communication
Submitted
23 Mha 2023
Accepted
30 Nhl 2023
First published
01 Huk 2023

Chem. Commun., 2023,59, 14169-14172

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Hyperbranched polyphthalocyanine micelles with dual PTT/PDT functions for bacteria eradication under an NIR window

Y. Du, G. Chu, R. Yu, R. Cui, Y. Wang, Y. Mai, M. Guan, F. Xu and Y. Zhou, Chem. Commun., 2023, 59, 14169 DOI: 10.1039/D3CC04082H

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