Issue 15, 2022
From the journal:

Biomaterials Science

Self-assembly of DNA nanogels with endogenous microRNA toehold self-regulating switches for targeted gene regulation therapy†

Jiaqi Yan,‡abc   Haixia Zou,‡a   Wenhui Zhou,‡c   Xiaowan Yuan,a   Zhijun Li,a   Xiaodong Ma,c   Chang Liu,c   Yonghui Wang,c   Jessica M. Rosenholm, ORCID logo c   Wenguo Cui, ORCID logo b   Xiangmeng Qu ORCID logo *a  and  Hongbo Zhang ORCID logo *bc  

* Corresponding authors

a Key Laboratory of Sensing Technology and Biomedical Instruments of Guangdong Province, School of Biomedical Engineering, Sun Yat-Sen University, 66 Gongchang Road, Shenzhen 518107, China
E-mail: quxm5@mail.sysu.cn

b Department of Radiology, Shanghai Institute of Traumatology and Orthopaedics, RuiJin Hospital, Shanghai Jiao Tong University, 149 ChongqingNan Road, Shanghai, PR China
E-mail: hongbo.zhang@abo.fi

c Pharmaceutical Sciences Laboratory and Turku Bioscience Center, Åbo Akademi University, FI-20520 Turku, Finland

Abstract

Herein, a smart nanohydrogel with endogenous microRNA-21 toehold is developed to encapsulate gemcitabine-loaded mesoporous silica nanoparticles for targeted pancreatic cancer therapy. This toehold mediated strand displacement method can simultaneously achieve specific drug release and miRNA-21 silencing, resulting in the up-regulation of the expression of tumor suppressor genes PTEN and PDCD4.

Graphical abstract: Self-assembly of DNA nanogels with endogenous microRNA toehold self-regulating switches for targeted gene regulation therapy

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Article information

DOI
https://doi.org/10.1039/D2BM00640E
Article type
Communication
Submitted
25 Dzi 2022
Accepted
18 Kho 2022
First published
20 Kho 2022
This article is Open Access
Creative Commons BY license

Biomater. Sci., 2022,10, 4119-4125

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Self-assembly of DNA nanogels with endogenous microRNA toehold self-regulating switches for targeted gene regulation therapy

J. Yan, H. Zou, W. Zhou, X. Yuan, Z. Li, X. Ma, C. Liu, Y. Wang, J. M. Rosenholm, W. Cui, X. Qu and H. Zhang, Biomater. Sci., 2022, 10, 4119 DOI: 10.1039/D2BM00640E

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