Issue 10, 2017

A bioorthogonal ‘turn-on’ fluorescent probe for tracking mitochondrial nitroxyl formation

Abstract

A bioreductant-resistant ‘turn-on’ chemodosimetric fluorescent probe Mito-1 has been developed for the detection of mitochondrial HNO in live cells. Mito-1 enables the detection of HNO as low as ∼18 nM. It has the capability to detect both exogenous and endogenous mitochondrial HNO formations in cellular milieus by providing fluorescence images. Its two-photon imaging ability fosters its use as a noninvasive imaging tool for the detection of mitochondrial nitroxyl.

Graphical abstract: A bioorthogonal ‘turn-on’ fluorescent probe for tracking mitochondrial nitroxyl formation

Supplementary files

Article information

Article type
Communication
Submitted
14 Huk 2016
Accepted
10 Sun 2017
First published
10 Sun 2017

Chem. Commun., 2017,53, 1723-1726

A bioorthogonal ‘turn-on’ fluorescent probe for tracking mitochondrial nitroxyl formation

K. Sunwoo, K. N. Bobba, J. Lim, T. Park, A. Podder, J. S. Heo, S. G. Lee, S. Bhuniya and J. S. Kim, Chem. Commun., 2017, 53, 1723 DOI: 10.1039/C6CC09082F

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