Issue 27, 2017

Enzymatic self-assembly of an immunoreceptor tyrosine-based inhibitory motif (ITIM)

Abstract

Here we show the first example of an immunoreceptor tyrosine-based inhibitory motif (ITIM), LYYYYL, as well as its enantiomeric or retro-inverso peptide, to self-assemble in water via enzyme-instructed self-assembly. Upon enzymatic dephosphorylation, the phosphohexapeptides become hexapeptides, which self-assemble in water to result in supramolecular hydrogels. This work illustrates a new approach to design bioinspired soft materials from a less explored, but important pool of immunomodulatory peptides.

Graphical abstract: Enzymatic self-assembly of an immunoreceptor tyrosine-based inhibitory motif (ITIM)

Supplementary files

Article information

Article type
Communication
Submitted
03 Mud 2017
Accepted
22 Kho 2017
First published
26 Kho 2017

Org. Biomol. Chem., 2017,15, 5689-5692

Enzymatic self-assembly of an immunoreceptor tyrosine-based inhibitory motif (ITIM)

N. Yamagata, X. Chen, J. Zhou, J. Li, X. Du and B. Xu, Org. Biomol. Chem., 2017, 15, 5689 DOI: 10.1039/C7OB01074E

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements