Issue 26, 2009

Nickel/AlMe2Cl-catalysed carbocyanation of alkynes using arylacetonitriles

Abstract

Nickel/Lewis acid dual catalysis was found to effect the carbocyanation reaction of alkynes using arylacetonitriles, giving a range of triply substituted acrylonitriles; the reaction of optically active α-phenylpropionitrile suggested a reaction mechanism that involves oxidative addition of a C–CN bond with retention of its absolute configuration.

Graphical abstract: Nickel/AlMe2Cl-catalysed carbocyanation of alkynes using arylacetonitriles

Supplementary files

Article information

Article type
Communication
Submitted
14 เม.ย. 2552
Accepted
05 พ.ค. 2552
First published
26 พ.ค. 2552

Chem. Commun., 2009, 3931-3933

Nickel/AlMe2Cl-catalysed carbocyanation of alkynes using arylacetonitriles

A. Yada, T. Yukawa, Y. Nakao and T. Hiyama, Chem. Commun., 2009, 3931 DOI: 10.1039/B907290J

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