Issue 8, 2024

Ultra-clean pure shift NMR with optimal water suppression for analysis of aqueous pharmaceutical samples

Abstract

Pure shift NMR experiments greatly enhance spectral resolution by collapsing multiplet structures into singlets and, with water suppression, can be used for aqueous samples. Here, we combine ultra-clean pure-shift NMR (SAPPHIRE) with two different internally encoded water suppression schemes to achieve optimal performance for small molecule and macrocyclic peptide pharmaceuticals in water and acetonitrile–water mixtures.

Graphical abstract: Ultra-clean pure shift NMR with optimal water suppression for analysis of aqueous pharmaceutical samples

Supplementary files

Article information

Article type
Communication
Submitted
12 ธ.ค. 2566
Accepted
04 มี.ค. 2567
First published
22 มี.ค. 2567

Analyst, 2024,149, 2227-2231

Ultra-clean pure shift NMR with optimal water suppression for analysis of aqueous pharmaceutical samples

G. Dal Poggetto, A. DiCaprio, M. Reibarkh and R. D. Cohen, Analyst, 2024, 149, 2227 DOI: 10.1039/D3AN02150E

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