Issue 10, 2017
From the journal:

Chemical Communications

A bioorthogonal ‘turn-on’ fluorescent probe for tracking mitochondrial nitroxyl formation†

Kyoung Sunwoo,‡a   Kondapa Naidu Bobba,‡b   Ja-Yun Lim,‡c   Taegun Park, ORCID logo c   Arup Podder,b   June Seok Heo,c   Seung Gwan Lee,*d   Sankarprasad Bhuniya ORCID logo *be  and  Jong Seung Kim ORCID logo *a  

* Corresponding authors

a Department of Chemistry, Korea University, Seoul 136-701, Korea
E-mail: jongskim@korea.ac.kr

b Amrita Centre for Industrial Research & Innovation, Amrita School of Engineering, Amrita Vishwa Vidyapeetham, Ettimadai, Coimbatore 641112, India
E-mail: b_sankarprasad@cb.amrita.edu

c Department of Integrated Biomedical and Life Sciences, College of Health Science, Korea University, Seoul 136-701, Korea

d Department of Health and Environmental Science, College of Health Science, Korea University, Seoul 136-701, Korea
E-mail: seunggwan@korea.ac.kr

e Department of Chemical Engineering and Materials Science, Amrita School of Engineering, Amrita Vishwa Vidyapeetham, Ettimadai, Coimbatore 641112, India

Abstract

A bioreductant-resistant ‘turn-on’ chemodosimetric fluorescent probe Mito-1 has been developed for the detection of mitochondrial HNO in live cells. Mito-1 enables the detection of HNO as low as ∼18 nM. It has the capability to detect both exogenous and endogenous mitochondrial HNO formations in cellular milieus by providing fluorescence images. Its two-photon imaging ability fosters its use as a noninvasive imaging tool for the detection of mitochondrial nitroxyl.

Graphical abstract: A bioorthogonal ‘turn-on’ fluorescent probe for tracking mitochondrial nitroxyl formation

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Article information

DOI
https://doi.org/10.1039/C6CC09082F
Article type
Communication
Submitted
14 พ.ย. 2559
Accepted
10 ม.ค. 2560
First published
10 ม.ค. 2560

Chem. Commun., 2017,53, 1723-1726

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A bioorthogonal ‘turn-on’ fluorescent probe for tracking mitochondrial nitroxyl formation

K. Sunwoo, K. N. Bobba, J. Lim, T. Park, A. Podder, J. S. Heo, S. G. Lee, S. Bhuniya and J. S. Kim, Chem. Commun., 2017, 53, 1723 DOI: 10.1039/C6CC09082F

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