Co-Catalyzed C(sp3)–C(sp2) bond cleavage via hydrogen atom transfer

Bingqing Zhou; Di Tian; Jinglin An; Yalan Zhou; Rui Yan; Hao Song; Xiao-Yu Liu; Yong Qin

doi:10.1039/D2QO00125J

You do not have JavaScript enabled. Please enable JavaScript to access the full features of the site or access our non-JavaScript page.

Co-Catalyzed C(sp³)–C(sp²) bond cleavage via hydrogen atom transfer†

Bingqing Zhou,‡^a Di Tian,‡^a Jinglin An,^a Yalan Zhou,^a Rui Yan,^a Hao Song,^a Xiao-Yu Liu

*^a and Yong Qin

*^a

Author affiliations

* Corresponding authors

^a Key Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry and Sichuan Province, Sichuan Engineering Laboratory for Plant-Sourced Drug and Sichuan Research Center for Drug Precision Industrial Technology, West China School of Pharmacy, Sichuan University, Chengdu 610041, Sichuan Province, China
E-mail: xyliu@scu.edu.cn, yongqin@scu.edu.cn

Abstract

The discovery of a new Co-catalyzed hydrogen atom transfer (HAT) C(sp³)–C(sp²) bond cleavage method to access ketones from alkenes is reported. This unprecedented transformation features mild reaction conditions and good functional group compatibility, and it proceeds through a key alkoxy radical formation and subsequent β-fragmentation approach.

This article is part of the themed collection: 2022 Organic Chemistry Frontiers HOT articles

Download options Please wait...

Supplementary files

Supplementary information PDF (5613K)

Article information

DOI: https://doi.org/10.1039/D2QO00125J
Article type: Research Article
Submitted: 24 ม.ค. 2565
Accepted: 05 มี.ค. 2565
First published: 08 มี.ค. 2565

Download Citation

Org. Chem. Front., 2022,9, 2135-2140

Permissions

Request permissions

Co-Catalyzed C(sp³)–C(sp²) bond cleavage via hydrogen atom transfer

B. Zhou, D. Tian, J. An, Y. Zhou, R. Yan, H. Song, X. Liu and Y. Qin, Org. Chem. Front., 2022, 9, 2135 DOI: 10.1039/D2QO00125J

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Social activity

Fetching data from CrossRef.
This may take some time to load.

Organic Chemistry Frontiers