Issue 8, 2022

Co-Catalyzed C(sp3)–C(sp2) bond cleavage via hydrogen atom transfer

Abstract

The discovery of a new Co-catalyzed hydrogen atom transfer (HAT) C(sp3)–C(sp2) bond cleavage method to access ketones from alkenes is reported. This unprecedented transformation features mild reaction conditions and good functional group compatibility, and it proceeds through a key alkoxy radical formation and subsequent β-fragmentation approach.

Graphical abstract: Co-Catalyzed C(sp3)–C(sp2) bond cleavage via hydrogen atom transfer

Supplementary files

Article information

Article type
Research Article
Submitted
24 ม.ค. 2565
Accepted
05 มี.ค. 2565
First published
08 มี.ค. 2565

Org. Chem. Front., 2022,9, 2135-2140

Co-Catalyzed C(sp3)–C(sp2) bond cleavage via hydrogen atom transfer

B. Zhou, D. Tian, J. An, Y. Zhou, R. Yan, H. Song, X. Liu and Y. Qin, Org. Chem. Front., 2022, 9, 2135 DOI: 10.1039/D2QO00125J

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