Issue 66, 2021

Tertiary cyclopropyl carbagermatranes: synthesis and cross-coupling

Abstract

The construction of the cyclopropyl quaternary carbon center can afford a series of 1,1-olefin bioisosteres. Here, we report tertiary cyclopropyl carbagermatranes, which can be easily obtained by the zinc-mediated decarboxylation of NHP esters. In addition, they exhibit efficient reactivity in the palladium-catalyzed cross-coupling reaction and orthogonal reactivity with boron reagents, therefore acting as robust nucleophiles for the synthesis of tertiary cyclopropane and efficient intermediates for the formation of quaternary centers.

Graphical abstract: Tertiary cyclopropyl carbagermatranes: synthesis and cross-coupling

Supplementary files

Article information

Article type
Communication
Submitted
03 มิ.ย. 2564
Accepted
07 ก.ค. 2564
First published
27 ก.ค. 2564

Chem. Commun., 2021,57, 8143-8146

Tertiary cyclopropyl carbagermatranes: synthesis and cross-coupling

S. Yang, W. Jiang and B. Xiao, Chem. Commun., 2021, 57, 8143 DOI: 10.1039/D1CC02930D

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