Issue 32, 2022

Native carboxyl group-assisted C–H acetoxylation of hydrocinnamic and phenylacetic acids

Abstract

The use of a native directing group to promote C–H activation is highly desirable. Herein, we report a method of native carboxyl-assisted, Pd(II)-catalyzed ortho-C–H acetoxylation of both hydrocinnamic and phenylacetic acids that can be found in many biologically active molecules as the key moieties. Based on the broad scope and the application potential showcased with drug molecules, it is anticipated that this C–H acetoxylation reaction will find attractive applicability in future synthetic endeavors.

Graphical abstract: Native carboxyl group-assisted C–H acetoxylation of hydrocinnamic and phenylacetic acids

Supplementary files

Article information

Article type
Communication
Submitted
23 ม.ค. 2565
Accepted
20 มี.ค. 2565
First published
21 มี.ค. 2565

Chem. Commun., 2022,58, 4993-4996

Native carboxyl group-assisted C–H acetoxylation of hydrocinnamic and phenylacetic acids

X. Wang, H. Wang, C. Zhou, L. Yang, L. Fu and G. Li, Chem. Commun., 2022, 58, 4993 DOI: 10.1039/D2CC00459C

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements