Themed collection Nanoscale and Nanoscale Horizons: Nanobiotechnology and Nanomedicine
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Integrated therapy platform of exosomal system: hybrid inorganic/organic nanoparticles with exosomes for cancer treatment
Hybrid inorganic/organic nanoparticles with exosomes can be applied as a novel platform for drug delivery systems. This biomimetic nanoplatform combines the functions of natural biomaterials to efficiently carry drugs to the center of cancer cells.
Nanoscale Horiz., 2022,7, 352-367
https://doi.org/10.1039/D1NH00637A
Advances in nanoparticle-based mRNA delivery for liver cancer and liver-associated infectious diseases
Nanoparticle-mediated mRNA delivery can increase the effectiveness of mRNA-based therapeutics and vaccines. These nanoparticles can deliver mRNA to treat liver diseases such as hepatocarcinoma and hepatotropic infections.
Nanoscale Horiz., 2023,8, 10-28
https://doi.org/10.1039/D2NH00289B
Engineered extracellular vesicles as intelligent nanosystems for next-generation nanomedicine
Engineered EVs containing an intelligent core have been designed to interact with a living host environment and function in an ideal situation. This review provides a new insight into design of next-generation EV-based theranostic platforms.
Nanoscale Horiz., 2022,7, 682-714
https://doi.org/10.1039/D2NH00070A
Phase-shift nanodroplets as an emerging sonoresponsive nanomaterial for imaging and drug delivery applications
The scheme of loading drugs/decorations in nanodroplets and US/laser irradiated drug release (figure created with BioRender.com).
Nanoscale, 2022,14, 2943-2965
https://doi.org/10.1039/D1NR07882H
Recent advances in nanotechnology-based COVID-19 vaccines and therapeutic antibodies
This review summarizes the nanotechnology-based COVID-19 vaccines and therapeutics, including protein nanoparticle-based vaccines, lipid nanoparticle-formulated mRNA vaccines, and nanobodies as unique therapeutic antibodies.
Nanoscale, 2022,14, 1054-1074
https://doi.org/10.1039/D1NR03831A
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Cell-free exosome-laden scaffolds for tissue repair
Exosome seeded on the designed scaffold can achieve local and sustained-release for efficient tissue repair.
Nanoscale, 2021,13, 8740-8750
https://doi.org/10.1039/D1NR01314A
Exosome-mediated delivery of gene vectors for gene therapy
Exosome encapsulation protects and delivers AAV vectors for gene therapy.
Nanoscale, 2021,13, 1387-1397
https://doi.org/10.1039/D0NR07622H
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Discrimination between protein glycoforms using lectin-functionalised gold nanoparticles as signal enhancers
Biolayer interferometry is used to distinguish between glycoforms of the same using lectin-functional nanoparticles as both readers, and signal enhancers. The use of this is exemplified with prostate specific antigen.
Nanoscale Horiz., 2023,8, 377-382
https://doi.org/10.1039/D2NH00470D
Attenuating endothelial leakiness with self-assembled DNA nanostructures for pulmonary arterial hypertension
Self-assembled DNA is constructed to attenuate pulmonary vascular remodeling by restoring the endothelial barriers. Self-assembled DNA inhibits HPAEC growth by the Atg101/Beclin-1/VE-cadherin pathway.
Nanoscale Horiz., 2023,8, 270-278
https://doi.org/10.1039/D2NH00348A
Polyclonal aptamer libraries as binding entities on a graphene FET based biosensor for the discrimination of apo- and holo-retinol binding protein 4
We report a sensor based on polyclonal aptamer libraries which is capable of label-free discrimination between retinol binding protein 4 isoforms (an important biomarker for kidney disease and diabetes) at sub-nM concentrations.
Nanoscale Horiz., 2022,7, 770-778
https://doi.org/10.1039/D1NH00605C
A novel phage display based platform for exosome diversity characterization
We present an innovative approach allowing the identification, isolation, and molecular characterization of disease-related exosomes based on their different antigenic reactivities.
Nanoscale, 2022,14, 2998-3003
https://doi.org/10.1039/D1NR06804K
Innovative transdermal delivery of insulin using gelatin methacrylate-based microneedle patches in mice and mini-pigs
Painless and controlled on-demand drug delivery is the ultimate goal for the management of various chronic diseases, including diabetes.
Nanoscale Horiz., 2022,7, 174-184
https://doi.org/10.1039/D1NH00596K
A self-amplifying nanodrug to manipulate the Janus-faced nature of ferroptosis for tumor therapy
A self-amplifying nanodrug was precisely designed to reprogram the Janus-faced nature of ferroptosis via harnessing the positive role of ferroptosis along with reversing its inherent negative role to achieve optimal ferroptotic tumor therapy.
Nanoscale Horiz., 2022,7, 198-210
https://doi.org/10.1039/D1NH00506E
Dual agonist immunostimulatory nanoparticles combine with PD1 blockade for curative neoadjuvant immunotherapy of aggressive cancers
Neoadjuvant combination immunotherapy based on a potent immunostimulatory nanoparticle resulted in significant efficacy, curative responses, and protective immunological memory.
Nanoscale, 2022,14, 1144-1159
https://doi.org/10.1039/D1NR06577G
Spatial confinement of chemically engineered cancer cells using large graphene oxide sheets: a new mode of cancer therapy
A concept of cancer treatment is developed by imposing large graphene oxide sheets as a “cage” on cancer cells to limit their spatial behavior through the inhibition of cell migration and invasion, which directly addresses the defining trait of cancer on the cellular level.
Nanoscale Horiz., 2021,6, 979-986
https://doi.org/10.1039/D1NH00350J
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Encapsulation of polyprodrugs enables an efficient and controlled release of dexamethasone
Encapsulation of pH-responsive polyprodrugs in semipermeable nanocontainers enables controlled release of water-soluble low molecular weight drugs under acidic conditions.
Nanoscale Horiz., 2021,6, 791-800
https://doi.org/10.1039/D1NH00266J
Tumor-targeted gene therapy with lipid nanoparticles inhibits tumor-associated adipocytes and remodels the immunosuppressive tumor microenvironment in triple-negative breast cancer
In breast cancer model, we identified C–C Motif Chemokine Ligand 2 (CCL2) as the key mediator which is secreted by tumor associated adipocytes, and developed targeted lipid-protamine-DNA (LPD) nanoparticles to locally “trap” CCL2 to ameliorate the immunosuppressive tumor microenvironment.
Nanoscale Horiz., 2021,6, 319-329
https://doi.org/10.1039/D0NH00588F
Immunostimulatory silica nanoparticle boosts innate immunity in brain tumors
An immunostimulatory nanoparticle was specifically designed to boost the local innate immune compartment of brain tumors leading to a robust antitumor immune response.
Nanoscale Horiz., 2021,6, 156-167
https://doi.org/10.1039/D0NH00446D
Cerium oxide nanozyme attenuates periodontal bone destruction by inhibiting the ROS–NFκB pathway
A detailed anti-inflammatory mechanism study of CeO2 nanozymes with reactive oxygen species scavenging abilities toward periodontitis treatment advances future nanozyme-based clinical applications.
Nanoscale, 2022,14, 2628-2637
https://doi.org/10.1039/D1NR06043K
Integration of a capacitor to a 3-D DNA walker and a biofuel cell-based self-powered system for ultrasensitive bioassays of microRNAs
A self-powered microRNA biosensor with triple signal amplification systems was assembled through the integration of three-dimensional DNA walkers, enzymatic biofuel cells and a capacitor.
Nanoscale, 2022,14, 815-822
https://doi.org/10.1039/D1NR06271A
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Surface enhanced Raman scattering of extracellular vesicles for cancer diagnostics despite isolation dependent lipoprotein contamination
SERS can “see through” varying lipoprotein contamination present in extracellular vesicles isolated from cancer patient samples for accurate diagnostic classification.
Nanoscale, 2021,13, 14760-14776
https://doi.org/10.1039/D1NR03334D
Hypoxia-specific anti-RAGE exosomes for nose-to-brain delivery of anti-miR-181a oligonucleotide in an ischemic stroke model
An exosome linked to RAGE-binding-peptide was developed as a hypoxia-specific carrier for nose-to-brain delivery of anti-microRNA oligonucleotide for ischemic stroke therapy.
Nanoscale, 2021,13, 14166-14178
https://doi.org/10.1039/D0NR07516G
In situ injection of dual-delivery PEG based MMP-2 sensitive hydrogels for enhanced tumor penetration and chemo-immune combination therapy
Improving the deep penetration of nanoparticles and realizing the combination of chemotherapy and immunotherapy have become a promising strategy for cancer treatment.
Nanoscale, 2021,13, 9577-9589
https://doi.org/10.1039/D1NR01155C
Doxorubicin and PD-L1 siRNA co-delivery with stem cell membrane-coated polydopamine nanoparticles for the targeted chemoimmunotherapy of PCa bone metastases
Polydopamine nanoparticles camouflaged with stem cell membranes could effectively target tumor sites and showed excellent performance in synergistic chemoimmunotherapy for PCa bone metastases.
Nanoscale, 2021,13, 8998-9008
https://doi.org/10.1039/D0NR08024A
A novel electrochemical lung cancer biomarker cytokeratin 19 fragment antigen 21-1 immunosensor based on Si3N4/MoS2 incorporated MWCNTs and core–shell type magnetic nanoparticles
Lung cancer is one of deadliest and most life threatening cancer types.
Nanoscale, 2021,13, 4660-4669
https://doi.org/10.1039/D1NR00244A
Layer-by-layer coated nanoliposomes for oral delivery of insulin
Nanosulin – a highly stable multilayer insulin-coated nanoliposome, enhanced insulin permeation across the intestinal epithelium and maintained bioactivity via oral administration in vivo.
Nanoscale, 2021,13, 776-789
https://doi.org/10.1039/D0NR06104B
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Local administration of stem cell-derived extracellular vesicles in a thermoresponsive hydrogel promotes a pro-healing effect in a rat model of colo-cutaneous post-surgical fistula
Local minimally-invasive EV delivery on a thermo-actuated PF-127 gel enhanced EV residence time in colo-cutaneous fistulas promoting a therapeutic effect.
Nanoscale, 2021,13, 218-232
https://doi.org/10.1039/D0NR07349K
Self-assembled chromogen-loaded polymeric cocoon for respiratory virus detection
Inspired by the self-assembly approach, in this work, the chromogen, 3,3′,5,5′-tetramethylbenzidine (TMB), was successfully co-precipitated in aqueous solution to form collective nanoparticles (NPs) of signal molecules (TMB-NPs).
Nanoscale, 2021,13, 388-396
https://doi.org/10.1039/D0NR06893D
About this collection
This online collection from Nanoscale and Nanoscale Horizons showcases some of the recent nanobiotechnology and nanomedicine papers published in the journals.
We hope you enjoy reading these articles!