Themed collection 2025 Nanoscale HOT Article Collection

Two-dimensional ferroelectric synaptic devices enabled by diverse coupling mechanisms
Two-dimensional (2D) van der Waals (vdW) ferroelectric (FE) materials have recently emerged as promising candidates for advanced synaptic devices in brain-inspired neuromorphic computing systems.
Nanoscale, 2025, Advance Article
https://doi.org/10.1039/D5NR02639C
Electrode reaction mechanisms in aqueous batteries: a comparative study and perspective on solid–solid versus solid–liquid–solid conversions
This work systematically compares solid–solid and solid–liquid–solid conversion mechanisms in aqueous batteries and provides new insights into designing high-performance aqueous energy storage systems.
Nanoscale, 2025, Advance Article
https://doi.org/10.1039/D5NR03170B
Integrating piezoelectric dressings with botanicals as emerging smart dressings for diabetic wound healing
Three aspects that piezoelectric materials promote wound healing are as follows: (A) electrical stimulation promotes tissue repair, (B) piezoelectric catalytic antibacterial action, and (C) drug-loaded piezoelectric dressings.
Nanoscale, 2025,17, 20044-20056
https://doi.org/10.1039/D5NR01797A
The application prospect of metal/metal oxide nanoparticles in the treatment of intervertebral disc degeneration
This review highlights the therapeutic potential of metal-based and metal oxide nanoparticles in IVDD by leveraging their antioxidant, anti-inflammatory, and microenvironment-modulating properties to enhance tissue repair. The ToC was created in BioRender. Zhang, L. (2025) https://BioRender.com/6fzdcqv.
Nanoscale, 2025,17, 15605-15616
https://doi.org/10.1039/D4NR05504G
Biomimetic ion channels with subnanometer sizes for ion sieving: a mini-review
The ion-selective transport property of biological systems has inspired the development of biomimetic ion channels. This mini-review highlights the mechanisms, recent fabrication strategies and applications of biomimetic ion channels.
Nanoscale, 2025,17, 9021-9039
https://doi.org/10.1039/D5NR00758E
Recent advances in multimodal mechanoluminescent sensors enabled by nanostructure design
Multifunctional coupling and signal decoupling achieved through nanostructure and supramolecule design, enable multimodal mechanoluminescent materials to play an increasingly important role in interdisciplinary applications and cutting-edge fields.
Nanoscale, 2025,17, 6414-6426
https://doi.org/10.1039/D4NR04875J

Data driven approaches in nanophotonics: a review of AI-enabled metadevices
AI surrogates are displacing brute-force simulations in meta-optics; we review strategies from CNNs to LLMs that speed design, capture coupling, and yield fabrication-friendly, multifunctional devices.
Nanoscale, 2025, Advance Article
https://doi.org/10.1039/D5NR02043C
Nanozyme-Driven Remodeling of the Immune Microenvironment: From Catalytic Therapy to Precise Immune Regulation
Nanoscale, 2025, Accepted Manuscript
https://doi.org/10.1039/D5NR03420E
Recent advances in mass-sensing humidity sensors: mechanisms, materials, and applications
In this review, mass-sensing humidity sensors are comprehensively summarized from the aspects of humidity sensing mechanisms, humidity sensing materials, and emerging applications. Images reproduced with permission, see Figure 1 for details.
Nanoscale, 2025, Advance Article
https://doi.org/10.1039/D5NR03048J
Acid-stable oxygen-evolving catalysts: progress in non-precious material engineering and scalability barriers
This work breaks new ground by linking catalyst design with engineering needs for proton exchange membrane water electrolyzers, providing a roadmap for non-precious catalysts in acid conditions.
Nanoscale, 2025, Advance Article
https://doi.org/10.1039/D5NR03118D
Tailoring MXenes for Energy Storage: Insights into Element Doping
Nanoscale, 2025, Accepted Manuscript
https://doi.org/10.1039/D5NR03386A
The curious case of anti-PEG antibodies
Humans are exposed to PEG and have ample opportunities to create anti-PEG antibodies.
Nanoscale, 2025, Advance Article
https://doi.org/10.1039/D5NR02301G
2D carbon-based dual pioneers: graphene oxide and graphdiyne guiding solar evaporation through three-dimensional mastery
Graphene oxide and graphdiyne enable solar evaporation through 3D mastery: broadband light harvesting, anisotropic heat confinement, and ion-selective water transport, reshaping optimization strategies for next-gen solar water-energy systems.
Nanoscale, 2025,17, 18981-18996
https://doi.org/10.1039/D5NR01104C
2D material-based infrared photodetectors: recent progress, challenges, and perspectives
2D materials-based infrared (IR) photodetectors are essential for a wide range of applications, including optical communication, night vision, and environmental monitoring; graphical images reproduced with permission; full details in paper.
Nanoscale, 2025,17, 17881-17918
https://doi.org/10.1039/D5NR01920F
Gallium-based nano-liquid metals enabled antimicrobial mechanisms and biomedical applications
This review summarizes the unique role of novel gallium-based nano-liquid metals in antibacterial applications, focusing on their distinctive activities and underlying antibacterial mechanisms. The graphical abstract was created in BioRender. R, z. (2025) https://BioRender.com/v96z429.
Nanoscale, 2025,17, 14441-14457
https://doi.org/10.1039/D5NR00406C
Inspiration of plant-related adhesion for plant wearable sensor interface design
This review presents a systematic framework outlining the construction strategies for adhesion layers in plant wearable devices, drawing inspiration from plant-based adhesion interfaces.
Nanoscale, 2025,17, 13057-13075
https://doi.org/10.1039/D5NR00359H
2D monolayer electrocatalysts for CO2 electroreduction
Through bridging the gap between 2D material and single-atom material, 2D monolayer materials exhibit great potential in CO2RR due to their unique structural/electronic properties, high atom utilization and low mass transfer resistance.
Nanoscale, 2025,17, 4212-4225
https://doi.org/10.1039/D4NR04109G
Recent advances in mRNA-based therapeutics for neurodegenerative diseases and brain tumors
mRNA-based therapeutics have entered the mainstream with seemingly limitless possibilities to treat neurodegenerative diseases and brain tumors.
Nanoscale, 2025,17, 3537-3548
https://doi.org/10.1039/D4NR04394D
Mechanical and electromechanical properties of 2D materials studied via in situ microscopy techniques
This review summarizes recent advancements in in situ microscopy techniques applied to the study of mechanical and electromechanical properties of 2D materials. The latest results, corresponding challenges and future opportunities are discussed.
Nanoscale, 2025,17, 1722-1763
https://doi.org/10.1039/D4NR03569K
From synthesis to chiroptical activities: advancements in circularly polarized luminescent inorganic quantum dots
Review of synthesis strategies for circularly polarized luminescence (CPL) inorganic quantum dots, influencing factors, theoretical insight into CPL mechanisms, and future applications/prospects. Images reproduced with permission, details in article.
Nanoscale, 2025,17, 158-186
https://doi.org/10.1039/D4NR03600J

Structural distortions control scaling of exciton binding energies in two-dimensional Ag/Bi double perovskites
Structural distortions in Ag/Bi quasi-2D double perovskites are responsible for the unexpected trend in the exciton binding energies.
Nanoscale, 2025, Advance Article
https://doi.org/10.1039/D5NR03010B
Colloidally synthesized and bandgap-engineered luminescent titanium nitride quantum dots
Nanoscale, 2025, Accepted Manuscript
https://doi.org/10.1039/D5NR03290C
Oxygen Vacancy-Enriched SnO2/NiO n-p Heterointerfaces for High-Efficiency Oxygen Evolution Reaction Catalysis
Nanoscale, 2025, Accepted Manuscript
https://doi.org/10.1039/D5NR03372A
Atomic engineering of trace endogenous Fe within natural clays into a self-supported Fe1–P single-atom cocatalyst for photocatalytic hydrogen evolution
The trace endogenous Fe species within natural halloysite nanotubes have been engineered into a single-atom Fe1–P cocatalyst with high H2 evolution activity and stability in both dye-sensitized and semiconductor-based systems.
Nanoscale, 2025, Advance Article
https://doi.org/10.1039/D5NR03464G
Designing a pseudocapacitive binary Zn/Mn perovskite fluoride anode with a conversion/alloying/insertion hybrid mechanism for advanced Na-ion capacitors and Na-based dual ion batteries
Designed a pseudocapacitive KZMF(3-1)@rGO anode material, explored its conversion/alloying/insertion hybrid mechanism by electrochemical analysis and ex situ characterization techniques, and constructed NICs and Na-DIBs devices.
Nanoscale, 2025,17, 21468-21474
https://doi.org/10.1039/D5NR03023D
Controllable syntheses of two structurally new {AsW9O33}-mediated silver alkynyl clusters
Two atomically-precise {AsW9O33}-mediated silver alkynyl clusters have been synthesized by adjusting mixed reaction solvents, showing efficient photothermal performance and catalytic activities towards the detoxification of 4-nitrophenol.
Nanoscale, 2025,17, 21475-21480
https://doi.org/10.1039/D5NR03313F

How octopod Mn–Fe oxide nanoparticle tracers minimize relaxation time and enhance MPI resolution
25 nm Octopod Mn–Fe oxide nanoparticles reduce crystal anisotropy, leading to faster relaxation times, a narrower MPI point spread function (PSF), and consequently improved spatial resolution.
Nanoscale, 2025,17, 21463-21467
https://doi.org/10.1039/D5NR02780B
Engineering gold nanosheets into bugle-like assemblies for plasmon-enhanced near-infrared oncology treatment
Low-symmetry, bugle-like gold nanocrystals fabricated by rolling Au nanosheets exhibit strong near-infrared absorption and outstanding photothermal therapeutic efficacy under 808 nm laser irradiation.
Nanoscale, 2025,17, 19117-19126
https://doi.org/10.1039/D5NR02366A
Unraveling a ligand-initiated oxidative etching pathway in gold nanoclusters
Thiol concentration governs the oxidative etching pathways of Au nanoclusters, switching between ligand-initiated and oxygen-initiated mechanisms, both leading to Au(I)-thiolate complexes via distinct intermediate steps.
Nanoscale, 2025,17, 19110-19116
https://doi.org/10.1039/D5NR02268A
Co-reduction coupling of bicarbonate and nitrate toward efficient urea synthesis
The spatial charge region is rationally designed by constructing a Mott–Schottky heterostructure in the Cu-WN catalyst, achieving accurate activation of NO3− and HCO3− to accelerate the targeted electrochemical C–N coupling reaction.
Nanoscale, 2025,17, 9086-9093
https://doi.org/10.1039/D4NR05196C
Lorentz force-assisted growth of romanesco-like Ni–Fe nano-cone arrays for enhanced oxygen evolution reaction at high current densities
A novel Lorentz-force-assisted electrodeposition method is introduced to fabricate Romanesco-like Ni–Fe nano-cone arrays with enhanced stability and efficient bubble release for the oxygen evolution reaction (OER) under high current densities.
Nanoscale, 2025,17, 8466-8475
https://doi.org/10.1039/D4NR05174B

Strong and reciprocal magneto-phonon effects in a 2D antiferromagnetic semiconductor FePSe3
Magnon–phonon coupling and spin-phonon interaction are interplays between phonons and magnetism, offering new approaches to manipulate phonons related to magnetism.
Nanoscale, 2025,17, 8476-8483
https://doi.org/10.1039/D4NR04743E
Mechanistic Insights into Plasmon-Driven Hot Electron Transfer from Silver Nanoclusters to PFAS: Interplay of Size and Electronic Structure
Nanoscale, 2025, Accepted Manuscript
https://doi.org/10.1039/D5NR03117F
Preparation and characterization of zein-based nano-assembled bioadhesive coatings for prolonged gastrointestinal retention of sinapine
Complex condensates based on zein can adhere to the intestine and prolong the residence time of sinapine.
Nanoscale, 2025, Advance Article
https://doi.org/10.1039/D5NR02630J
Sub-5 nm monolayer SnNX (X=Cl, Br)-based homogeneous CMOS devices
Nanoscale, 2025, Accepted Manuscript
https://doi.org/10.1039/D5NR03257A
Polarization-Sensitive Photodetector Based on b-AsP/In2Se3 Heterostructure
Nanoscale, 2025, Accepted Manuscript
https://doi.org/10.1039/D5NR02575C
Enhanced stretchability and stability of micro hole mesh electrodes via a crack-guiding notch design
Nanoscale, 2025, Accepted Manuscript
https://doi.org/10.1039/D5NR02993G
Pt nanoparticle–nanowire hybrids supported on single-walled carbon nanotubes for enhanced oxygen reduction reaction in polymer electrolyte fuel cells
The Pt nanoparticle–nanowire hybrid on SWCNTs combines high activity, efficient electron transport, and durability, achieving a 0.882 V half-wave potential, a 380 A gPt−1 mass activity, and retaining performance after 60 000 cycles.
Nanoscale, 2025, Advance Article
https://doi.org/10.1039/D5NR02497H
Unveiling the potential of a discrete titania chemiresistor: broad-spectrum sensing of C1–C4 alcohols and precise C3 isomer discrimination in binary mixtures
This study explores SMO chemiresistors for detecting C1–C4 alcohols, distinguishing C3 isomers and quantifying their mixtures. 1-Butanol shows the highest response at 300 °C, while 1-propanol outperforms 2-propanol.
Nanoscale, 2025, Advance Article
https://doi.org/10.1039/D5NR02854J

Hole scavenger concentration dependent photoreduction pathway of nitrobenzene catalyzed by CdS quantum dots
The concentration of hole scavenger Na2SO3 in nitrobenzene photoreduction catalyzed by CdS quantum dots determines reaction selectivity, highlighting how scavenger quantity can direct photocatalytic pathways.
Nanoscale, 2025,17, 22260-22270
https://doi.org/10.1039/D5NR03085D

Harnessing light in tandem: advanced erbium-polyaniline QD composites for next-generation energy storage
Marked improvement in electrochemical performance of erbium ions with stable PANI quantum dots (8 nm).
Nanoscale, 2025,17, 22203-22217
https://doi.org/10.1039/D5NR02298C
Integration of Bi2Te3 nanosheets with laser desorption/ionization mass spectrometry for sensitive glucose detection in soft drinks
Accurate and sensitive detection of small biomolecules such as saccharides in foods and beverages remains difficult due to poor ionization and spectral interference in conventional organic matrix-based LDI-MS.
Nanoscale, 2025,17, 22190-22202
https://doi.org/10.1039/D5NR02988K
Carbon dots endow glucose oxidase with autocatalytic features and anti-poisoning ability
Carbon dots regulate glucose oxidase via H2O2 decomposition and O2 regeneration to build an autocatalytic cycle, enabling high-performance bioelectrocatalytic and immobilized enzyme systems.
Nanoscale, 2025, Advance Article
https://doi.org/10.1039/D5NR03031E

Shape effects on the 2D self-assembly of lithographically fabricated nanoparticles
Lithographically-defined polygonal Au nanoplates assemble at liquid-air interface. Shape governs 2D order: hexagonal>pentagonal>square, correlated with coordination/tiling. Binary mixtures with compatible six-fold coordination show enhanced ordering.
Nanoscale, 2025, Advance Article
https://doi.org/10.1039/D5NR03413B
Computational screening of M2N4-C-type dual-atom-catalysts for electrochemical ammonia synthesis by the first-principles DFT and machine learning
Nanoscale, 2025, Accepted Manuscript
https://doi.org/10.1039/D5NR03036F
Formation of Covalent Ga-C Bonds on Liquid Metal Nanoparticles with Enhanced Stability and Anti-Oxidation
Nanoscale, 2025, Accepted Manuscript
https://doi.org/10.1039/D5NR03476K

Comparative analysis of synthesis techniques for citrate-capped gold nanoparticles: insights into optimized wet-chemical approaches for controlled morphology and stability
This study evaluates six methods for the synthesis of citratestabilized AuNPs, demonstrating how reagent order, reducing agent identity, and citrate concentration collectively govern particle size, dispersity, and colloidal stability.
Nanoscale, 2025, Advance Article
https://doi.org/10.1039/D5NR02727F
Graphene quantum dots covalently functionalized with zinc porphyrin for digital-analog dual-mode memristors
We report a digital–analog dual-mode memristor based on a donor–acceptor structured nanomaterial, ZnTPP-g-GQDs, which is synthesized through the covalent functionalization of graphene quantum dots with zinc porphyrin.
Nanoscale, 2025, Advance Article
https://doi.org/10.1039/D5NR02683K
Theoretical design of the nonlinear Janus metastructure based on second harmonic generation with difference detection
Schematic of the NJM. The entire structure is represented as (AB)NP1ABP2ABP1(AB)NC.
Nanoscale, 2025, Advance Article
https://doi.org/10.1039/D5NR02558C
Single-atom iron nanozyme with oxidase-like activity for ultrasensitive polyphenol detection
Nanoscale, 2025, Accepted Manuscript
https://doi.org/10.1039/D5NR02482J
Fully compensated ferrimagnetism in a Cr2TiC2 monolayer MXene
Fully compensated ferrimagnets have the combined advantages of the band spin splitting of ferromagnetism and the zero net magnetization of antiferromagnetism, which endows them with numerous advantages in fast and energy-efficient spintronic devices.
Nanoscale, 2025, Advance Article
https://doi.org/10.1039/D5NR02850G
Temperature-dependent structural and morphological engineering of nickel nitride via nitrogen plasma processing for efficient electrocatalysis
A facile cooling-mediated plasma strategy is applied to simply modulate the exposed facets and morphology of the achieved nickel nitride nano-frameworks for controllable HER and OER behaviors.
Nanoscale, 2025,17, 21506-21515
https://doi.org/10.1039/D5NR02908B
Femtosecond laser constructed bioinspired gradient wedge-shaped surfaces for under-oil liquid self-transport
Inspired by lotus leaves and cactus spines, we propose a bionic superwetting gradient wedge-shaped surface (SGWS) for self-transport of liquids under-oil, which shows great potential for microfluidic chips and multi-functional applications.
Nanoscale, 2025,17, 21494-21505
https://doi.org/10.1039/D5NR02015H
A data-driven machine learning approach for predictive modeling of transition metal dichalcogenide/carbon composite supercapacitor electrodes
A comprehensive machine learning framework was reported to predict the electrochemical performance of transition metal dichalcogenide/carbon composite supercapacitor electrodes.
Nanoscale, 2025, Advance Article
https://doi.org/10.1039/D5NR03149D
Isomer-driven supramolecular polymorphism of 4-hydroxytamoxifen modulating nanostructure-dependent cellular uptake and cytotoxicity
The efficacy of 4-OHT is influenced by its supramolecular structure, not just receptor affinity. Isomer-specific assemblies create amorphous nanoflakes (Z-form) with high uptake and crystalline nanoribbons (E-form) with limited bioactivity.
Nanoscale, 2025, Advance Article
https://doi.org/10.1039/D5NR02944A
Efficient synthesis of kilogram-scale high-performance Na3V2O2(PO4)2F as a cathode material for sodium-ion batteries
Na3V2O2(PO4)2F (NVOPF) has garnered significant attention in the field of sodium-ion battery cathode materials due to its high operating voltage and exceptional cycling stability.
Nanoscale, 2025, Advance Article
https://doi.org/10.1039/D5NR02889B
Boosting nanoparticle yield: enhanced atom-to-nanoparticle conversion in gas aggregation
Pulsed magnetron sputtering can boost nanoparticle yield by factor of 10 without increasing material or energy input.
Nanoscale, 2025, Advance Article
https://doi.org/10.1039/D5NR02126J
The design and construction of Co(OH)2@NiFe-MIL/NFF heterostructure catalyst for efficient and ultrastable water oxidation
Nanoscale, 2025, Accepted Manuscript
https://doi.org/10.1039/D5NR03519H
Gradient bandgap engineering for performance enhancement in PbSe photodetectors
Gradient bandgap engineering significantly enhances the performance of PbSe short-wave infrared detectors, laying the foundation for their practical applications.
Nanoscale, 2025, Advance Article
https://doi.org/10.1039/D5NR02942B

Tunable and robust optical and structural properties of a cooperative squaraine-dye aggregate-DNA DX-DAE tile system
Comprehensive study of a squaraine-dye-labeled DNA DX-tile aggregate system, including cooperative self-assembly of a double-tile, in solution and solid phase.
Nanoscale, 2025,17, 18646-18677
https://doi.org/10.1039/D5NR00863H
High entropy rare-earth Prussian blue analogues for boosting oxygen evolution catalysis
High-entropy PBAs containing Ni, Fe, La, Mo, and Co were prepared via a co-precipitation method. This specific elemental combination facilitates the adsorption and reaction of OH− ions, thereby reducing the overpotential of OER.
Nanoscale, 2025,17, 18623-18632
https://doi.org/10.1039/D5NR01719J

Influence of ethylene thermal decomposition on carbon nanotube growth: insights from a two-zone reactor study
Gas-phase decomposition of the carbon precursor is a critical yet not fully understood step in growth of carbon nanotubes (CNTs). We present a systematic investigation of how the thermal decomposition of C2H4 influences CNT growth.
Nanoscale, 2025,17, 18614-18622
https://doi.org/10.1039/D5NR02143J
Facile synthesis of magnetic core–shell structures for tunable microwave absorption
SnCo/C@MoS2 with core-shell structure had the RLmin of −64.27 dB, the EAB of 5.20 GHz and the RCS value below −20 dBm2, exhibiting remarkable microwave absorption properties.
Nanoscale, 2025,17, 18633-18645
https://doi.org/10.1039/D5NR01174D
Covalently bonded graphene oxide–carbon nanotube hybrid nanofillers for achieving high-performance polyamide 6 composites with superior mechanical properties and thermal conductivity
High-performance PA6 composites are achieved through strong nanofiller–nanofiller and nanofiller–matrix interfaces.
Nanoscale, 2025,17, 18127-18142
https://doi.org/10.1039/D5NR02405F
Charges on a suspended silicon nitride membrane under a high-energy electron beam
Quantitative charge analysis reveals stable residual and localized charges on SiNx membranes under a high-energy electron beam, which could influence particle dynamics, mass transport, particle nucleation and growth in gas and liquid phase TEM.
Nanoscale, 2025, Advance Article
https://doi.org/10.1039/D5NR01742D
Interface-engineered Bi2O3/N-doped carbon heterostructure enabling synergistic effects for advanced energy storage
Metal oxide/carbon nanocomposites have emerged as prospective electrodes for electrochemical energy storage.
Nanoscale, 2025,17, 17568-17578
https://doi.org/10.1039/D5NR02479J
Physicochemical characterization of a new porous 2D semiconductor carbon allotrope, C16: an investigation via density functional theory and machine learning-based molecular dynamics
This study comprehensively characterizes, with suggested applications, a novel two-dimensional carbon allotrope, C16, using density functional theory and machine learning-based molecular dynamics.
Nanoscale, 2025,17, 14660-14675
https://doi.org/10.1039/D5NR01282A
Stepwise electrochemical reconstruction of a Bi-based anode for enhanced aqueous battery energy storage
BiOx@BiO/Bi nanoflakes are prepared by electrochemical reconstruction, showing a flower open and close structral evolution in charge and discharge process and excellent electrochemical performance.
Nanoscale, 2025,17, 14676-14686
https://doi.org/10.1039/D5NR00601E
In situ growth of enzyme-inorganic hybrid nanoflowers on paper strips for the visual detection of saliva-level glucose
This study innovates an in situ growth method of multi-enzyme-inorganic hybrid nanoflowers (HNFs) on cellulose paper, boosting enzyme immobilization efficiency and advancing diabetes diagnostics.
Nanoscale, 2025,17, 13698-13707
https://doi.org/10.1039/D5NR01340B
A ZIF-8-based dual-modal smart responsive nanoplatform for overcoming radiotherapy resistance in advanced tumors
ZIF-8-based dual-modality biomimetic smart nanoparticles loaded with ICG and rapamycin are used for the combination therapy of radiation sensitization and photothermal therapy of advanced tumors.
Nanoscale, 2025,17, 12134-12148
https://doi.org/10.1039/D5NR01093D
About this collection
This ongoing web collection features all the articles published in Nanoscale in 2025 that have been highlighted as HOT by our reviewers. Congratulations to all the authors whose articles are featured!