Issue 25, 2015
From the journal:

Journal of Materials Chemistry B

Photostable AIE fluorogens for accurate and sensitive detection of S-phase DNA synthesis and cell proliferation†

Yueyue Zhao,ab   Chris Y. Y. Yu,ab   Ryan T. K. Kwok,ab   Yilong Chen,ab   Sijie Chen,ab   Jacky W. Y. Lamab  and  Ben Zhong Tang*abc  

* Corresponding authors

a Department of Chemistry, Institute for Advanced Study, Division of Biomedical Engineering, Division of Life Science, State Key Laboratory of Molecular Neuroscience, Institute of Molecular Functional Materials, The Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong, China
E-mail: tangbenz@ust.hk

b Guangdong Innovative Research Team, SCUT-HKUST Joint Research Laboratory, State Key Laboratory of Luminescent Materials and Devices, South China University of Technology, Guangzhou 510640, China

c HKUST Shenzhen Research Institute, No. 9 Yuexing First RD, South Area, Hi-tech Park, Nanshan, Shenzhen 518057, China

Abstract

Two azide-functionalized tetraphenylethene derivatives with AIE features are synthesized and used as fluorescent agents for detecting S-phase DNA synthesis and cell proliferation based on EdU assay. Compared to the Alexa-azide dye, a commercial DNA bioprobe, the AIE fluorogens show better photostability and sensitivity, making them promising alternatives.

Graphical abstract: Photostable AIE fluorogens for accurate and sensitive detection of S-phase DNA synthesis and cell proliferation

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Supplementary files

Article information

DOI
https://doi.org/10.1039/C5TB00458F
Article type
Communication
Submitted
12 Mac 2015
Accepted
14 Apr 2015
First published
14 Apr 2015

J. Mater. Chem. B, 2015,3, 4993-4996

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Photostable AIE fluorogens for accurate and sensitive detection of S-phase DNA synthesis and cell proliferation

Y. Zhao, C. Y. Y. Yu, R. T. K. Kwok, Y. Chen, S. Chen, J. W. Y. Lam and B. Z. Tang, J. Mater. Chem. B, 2015, 3, 4993 DOI: 10.1039/C5TB00458F

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