Issue 12, 2023

Synthesis of 3-selanyl-isoflavones from 2-hydroxyphenyl enaminones using trichloroisocyanuric acid (TCCA): a sustainable approach

Abstract

We hereby present an original and sustainable synthetic methodology for the synthesis of 3-selanyl-isoflavones from 2-hydroxyphenyl enaminones and diorganoyl diselenides. The reaction is promoted in a one-pot manner by the greener reagent trichloroisocyanuric acid and employs ethanol as a solvent under mild conditions. Using this protocol, 22 examples of 3-selanyl-isoflavones were prepared in 34%–95% yields.

Graphical abstract: Synthesis of 3-selanyl-isoflavones from 2-hydroxyphenyl enaminones using trichloroisocyanuric acid (TCCA): a sustainable approach

Supplementary files

Article information

Article type
Communication
Submitted
12 Des 2022
Accepted
07 Feb 2023
First published
08 Feb 2023

New J. Chem., 2023,47, 5598-5602

Synthesis of 3-selanyl-isoflavones from 2-hydroxyphenyl enaminones using trichloroisocyanuric acid (TCCA): a sustainable approach

C. V. Doerner, J. S. S. Neto, C. R. Cabreira, S. Saba, L. P. Sandjo, J. Rafique, A. L. Braga and F. F. de Assis, New J. Chem., 2023, 47, 5598 DOI: 10.1039/D2NJ06043D

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