Issue 12, 2023

Azulene tethered N-aryl nucleobases: synthesis, morphology and biochemical evaluations

Abstract

Azulene is a non-benzenoid aromatic molecule comprising unique structural and functional properties. Herein, we report four new azulene-based N-aryl nucleobases via nucleophilic aromatic substitution (SNAr) exhibiting distinct morphologies with no cytotoxic effect toward the HEK293T cell line. The silver complex of the cytosine derivative, i.e. the silver nanocomposite (Ag–C-complex), has also been synthesized, showing antibacterial properties against Pseudomonas aeruginosa (PA14) with a minimum inhibitory concentration of 20 µM.

Graphical abstract: Azulene tethered N-aryl nucleobases: synthesis, morphology and biochemical evaluations

Supplementary files

Article information

Article type
Communication
Submitted
23 Dec 2022
Accepted
09 Feb 2023
First published
10 Feb 2023

New J. Chem., 2023,47, 5593-5597

Azulene tethered N-aryl nucleobases: synthesis, morphology and biochemical evaluations

S. Meher and N. K. Sharma, New J. Chem., 2023, 47, 5593 DOI: 10.1039/D2NJ06272K

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